A nickel-catalyzed three-component reductive carbonylation of alkyl halides, aryl halides, and ethyl chloroformate is described. Ethyl chloroformate is utilized as a safe and readily available source of CO in this multi-component protocol, providing an efficient and practical alternative for the synthesis of aryl-alkyl ketones. The reaction exhibits a wide substrate scope and good functional group compatibility. Experimental and DFT mechanistic studies highlight the complexity the cross-electrophile coupling and provide insight into the sequence of the three consecutive oxidative additions of aryl halide, chloroformate and akyl halide.
|Original language||English (US)|
|Journal||Angewandte Chemie International Edition|
|State||Published - Jun 21 2022|
Bibliographical noteKAUST Repository Item: Exported on 2022-06-23
Acknowledgements: The authors thank the King Abdullah University of Science and Technology (KAUST) for financial support and the KAUST Supercomputing Laboratory for providing the computational resources of the Shaheen II supercomputer.
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