Reactivity in Nickel Catalyzed Multicomponent Sequential Reductive Cross-Coupling Reactions

Haifeng Chen, Huifeng Yue, Chen Zhu, Magnus Rueping

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


A nickel-catalyzed three-component reductive carbonylation of alkyl halides, aryl halides, and ethyl chloroformate is described. Ethyl chloroformate is utilized as a safe and readily available source of CO in this multi-component protocol, providing an efficient and practical alternative for the synthesis of aryl-alkyl ketones. The reaction exhibits a wide substrate scope and good functional group compatibility. Experimental and DFT mechanistic studies highlight the complexity the cross-electrophile coupling and provide insight into the sequence of the three consecutive oxidative additions of aryl halide, chloroformate and akyl halide.
Original languageEnglish (US)
JournalAngewandte Chemie International Edition
StatePublished - Jun 21 2022

Bibliographical note

KAUST Repository Item: Exported on 2022-06-23
Acknowledgements: The authors thank the King Abdullah University of Science and Technology (KAUST) for financial support and the KAUST Supercomputing Laboratory for providing the computational resources of the Shaheen II supercomputer.

ASJC Scopus subject areas

  • General Chemistry
  • Catalysis


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