This focused review aims to summarize recent developments in the processes involving additions of secondary propargylamines to various heteroallenes and subsequent transition metal-catalyzed or electrophile-mediated cyclizations. The utility of this convenient and tunable strategy spans from the carbon dioxide fixation and target-oriented synthesis of complex natural and biologically active products to the generation of extended synthetic libraries of diverse oxygen-, nitrogen- and sulfur-containing heterocycles. For comparative purposes, the analogous transformations of propargylic alcohols are also highlighted in this account.
Bibliographical noteKAUST Repository Item: Exported on 2020-10-01
Acknowledgements: Support was provided by the Startup Fund from Soochow University (grant Q410900714), the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), the Project of Scientific and Technologic Infrastructure of Suzhou (grant SZS201708), the Fund for Scientific Research-Flanders (FWO), the Research Fund of the University of Leuven (KU Leuven) and by the Ministry of Education and Science of the Russian Federation (the agreement number 02.a03.0008). A. A. N. is grateful to the European Community Mobility Program “Erasmus Mundus Action 2, Strand 1”.