Raman on suspended DNA: Novel super-hydrophobic approach for structural studies

Monica Marini, Marco Allione, Bruno Torre, Manola Moretti, Tania Limongi, Luca Tirinato, Andrea Giugni, Gobind Das, Enzo M. Di Fabrizio

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The A- and B-form are two of the most common structural conformations of double strand DNA present in nature and they can interchange on the basis of the helices hydration [1,2]. Herein we demonstrate that the use of non-destructive techniques such as Raman spectroscopy coupled with the use of a super-hydrophobic device, allows the clear identification of the DNA hydration state, of the backbone (phosphate + deoxyribose sugar) conformation and of the nucleotides. There is a wide prospect for an increase of knowledge in biomolecules using this combined approach resulting in a significant impact in the study of more complex supramolecular assemblies and of fine chemical variation along the genomic loci undergoing to epigenetic variations.
Original languageEnglish (US)
Pages (from-to)38-42
Number of pages5
JournalMicroelectronic Engineering
StatePublished - Dec 24 2016

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: The authors acknowledge financial support from the KAUST start-up funding and from Ministry of Health, Italy under the projects: Project no.: GR-2010-2320665 and Project no.: GR-2010-2311677.


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