Radical fringe positions the apical ectodermal ridge at the dorsoventral boundary of the vertebrate limb

Concepción Rodriguez-Esteban, John W.R. Schwabe, Jennifer De La Peña, Bryon Foys, Brian Eshelman, Juan Carlos Izpisua Belmonte

Research output: Contribution to journalArticlepeer-review

169 Scopus citations


Vertebrate limb outgrowth requires a structure called the apical ectodermal ridge, formation of which follows the previous establishment of the dorsoventral limb axis. Radical fringe is expressed in the dorsal ectoderm before the ridge appears, and is repressed by Engrailed-I, which is expressed in the ventral ectoderm. Misexpression of these genes indicates that a ridge is formed wherever there is s boundary between cells expressing and not expressing Radical fringe. Thus, as in Drosophila, Radical fringe positions the ridge at the dorsoventral limb boundary.

Original languageEnglish (US)
Pages (from-to)360-366
Number of pages7
Issue number6623
StatePublished - Mar 27 1997

ASJC Scopus subject areas

  • Medicine(all)
  • General

Cite this