Racial differences in markers of mineral metabolism in advanced chronic kidney disease

Anna Jovanovich; Michel Chonchol; Alfred K. Cheung; James S. Kaufman; Tom Greene; William L. Roberts; Gerard Smits; Jessica Kendrick

doi:10.2215/CJN.07020711

Racial differences in markers of mineral metabolism in advanced chronic kidney disease

Anna Jovanovich, Michel Chonchol, Alfred K. Cheung, James S. Kaufman, Tom Greene, William L. Roberts, Gerard Smits, Jessica Kendrick

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Background and objectives This study examined differences in the concentration of markers of mineral metabolism across race in patients with advanced CKD not requiring dialysis and ESRD. Design, setting, participants, & measurements Concentrations of 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH) 2D), intact parathyroid hormone (iPTH), and fibroblast growth factor 23 (FGF-23) were measured in stored plasma samples of 1497 patients with advanced CKD not yet on dialysis and ESRD who participated in the Homocysteine in Kidney and End Stage Renal Disease study. Linear regression models were used to examine the relationship between race and 25(OH)D, 1,25(OH) 2D, iPTH, and FGF-23 concentrations. Results Non-Hispanic white patients comprised 58% of the cohort, whereas non-Hispanic blacks comprised 42%. Median (interquartile range) FGF-23 concentrations were lower in blacks compared with whites with CKD (323 [181-655] versus 431 [232-1026] RU/ml; P

Original language	English (US)
Pages (from-to)	640-647
Number of pages	8
Journal	Clinical Journal of the American Society of Nephrology
Volume	7
Issue number	4
DOIs	https://doi.org/10.2215/CJN.07020711
State	Published - Apr 1 2012
Externally published	Yes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-09-20

ASJC Scopus subject areas

General Medicine
Critical Care and Intensive Care Medicine
Epidemiology
Nephrology
Transplantation

Access to Document

10.2215/CJN.07020711

Cite this

@article{fc56bf972258430fa4d6d12f7b78ac06,

title = "Racial differences in markers of mineral metabolism in advanced chronic kidney disease",

abstract = "Background and objectives This study examined differences in the concentration of markers of mineral metabolism across race in patients with advanced CKD not requiring dialysis and ESRD. Design, setting, participants, & measurements Concentrations of 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH) 2D), intact parathyroid hormone (iPTH), and fibroblast growth factor 23 (FGF-23) were measured in stored plasma samples of 1497 patients with advanced CKD not yet on dialysis and ESRD who participated in the Homocysteine in Kidney and End Stage Renal Disease study. Linear regression models were used to examine the relationship between race and 25(OH)D, 1,25(OH) 2D, iPTH, and FGF-23 concentrations. Results Non-Hispanic white patients comprised 58% of the cohort, whereas non-Hispanic blacks comprised 42%. Median (interquartile range) FGF-23 concentrations were lower in blacks compared with whites with CKD (323 [181-655] versus 431 [232-1026] RU/ml; P",

author = "Anna Jovanovich and Michel Chonchol and Cheung, {Alfred K.} and Kaufman, {James S.} and Tom Greene and Roberts, {William L.} and Gerard Smits and Jessica Kendrick",

note = "Generated from Scopus record by KAUST IRTS on 2023-09-20",

year = "2012",

month = apr,

day = "1",

doi = "10.2215/CJN.07020711",

language = "English (US)",

volume = "7",

pages = "640--647",

journal = "Clinical Journal of the American Society of Nephrology",

issn = "1555-9041",

publisher = "American Society of Nephrology",

number = "4",

}

TY - JOUR

T1 - Racial differences in markers of mineral metabolism in advanced chronic kidney disease

AU - Jovanovich, Anna

AU - Chonchol, Michel

AU - Cheung, Alfred K.

AU - Kaufman, James S.

AU - Greene, Tom

AU - Roberts, William L.

AU - Smits, Gerard

AU - Kendrick, Jessica

N1 - Generated from Scopus record by KAUST IRTS on 2023-09-20

PY - 2012/4/1

Y1 - 2012/4/1

N2 - Background and objectives This study examined differences in the concentration of markers of mineral metabolism across race in patients with advanced CKD not requiring dialysis and ESRD. Design, setting, participants, & measurements Concentrations of 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH) 2D), intact parathyroid hormone (iPTH), and fibroblast growth factor 23 (FGF-23) were measured in stored plasma samples of 1497 patients with advanced CKD not yet on dialysis and ESRD who participated in the Homocysteine in Kidney and End Stage Renal Disease study. Linear regression models were used to examine the relationship between race and 25(OH)D, 1,25(OH) 2D, iPTH, and FGF-23 concentrations. Results Non-Hispanic white patients comprised 58% of the cohort, whereas non-Hispanic blacks comprised 42%. Median (interquartile range) FGF-23 concentrations were lower in blacks compared with whites with CKD (323 [181-655] versus 431 [232-1026] RU/ml; P

AB - Background and objectives This study examined differences in the concentration of markers of mineral metabolism across race in patients with advanced CKD not requiring dialysis and ESRD. Design, setting, participants, & measurements Concentrations of 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH) 2D), intact parathyroid hormone (iPTH), and fibroblast growth factor 23 (FGF-23) were measured in stored plasma samples of 1497 patients with advanced CKD not yet on dialysis and ESRD who participated in the Homocysteine in Kidney and End Stage Renal Disease study. Linear regression models were used to examine the relationship between race and 25(OH)D, 1,25(OH) 2D, iPTH, and FGF-23 concentrations. Results Non-Hispanic white patients comprised 58% of the cohort, whereas non-Hispanic blacks comprised 42%. Median (interquartile range) FGF-23 concentrations were lower in blacks compared with whites with CKD (323 [181-655] versus 431 [232-1026] RU/ml; P

UR - https://journals.lww.com/01277230-201204000-00018

UR - http://www.scopus.com/inward/record.url?scp=84859554593&partnerID=8YFLogxK

U2 - 10.2215/CJN.07020711

DO - 10.2215/CJN.07020711

M3 - Article

SN - 1555-9041

VL - 7

SP - 640

EP - 647

JO - Clinical Journal of the American Society of Nephrology

JF - Clinical Journal of the American Society of Nephrology

IS - 4

ER -

Racial differences in markers of mineral metabolism in advanced chronic kidney disease

Abstract

Bibliographical note

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this