Racemic alcohols to optically pure amine precursors enabled by catalyst dynamic kinetic resolution: experiment and computation

Luis Miguel Azofra; Mai Anh Tran; Viktoriia Zubar; Luigi Cavallo; Magnus Rueping; Osama El-Sepelgy

doi:10.1039/d0cc02881a

Racemic alcohols to optically pure amine precursors enabled by catalyst dynamic kinetic resolution: experiment and computation

Luis Miguel Azofra, Mai Anh Tran, Viktoriia Zubar, Luigi Cavallo, Magnus Rueping, Osama El-Sepelgy

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Abstract

An unprecedented base metal catalysed asymmetric synthesis of α-chiral amine precursors from racemic alcohols is reported. This redox-neutral reaction utilises a bench-stable manganese complex and Ellman’s sulfinamide as versatile ammonia...

Original language	English (US)
Journal	Chemical Communications
DOIs	https://doi.org/10.1039/d0cc02881a
State	Published - Jun 29 2020

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: L.M.A thank Universidad de Las Palmas de Gran Canaria (ULPGC) for support. Gratitude is also due to the KAUST for using the supercomputer Shaheen II for providing the computational resources.

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10.1039/d0cc02881a

https://repository.kaust.edu.sa/bitstream/10754/664013/1/Racemic_Racemic%20alcohols.pdf

Cite this

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title = "Racemic alcohols to optically pure amine precursors enabled by catalyst dynamic kinetic resolution: experiment and computation",

abstract = "An unprecedented base metal catalysed asymmetric synthesis of α-chiral amine precursors from racemic alcohols is reported. This redox-neutral reaction utilises a bench-stable manganese complex and Ellman{\textquoteright}s sulfinamide as versatile ammonia...",

author = "Azofra, {Luis Miguel} and Tran, {Mai Anh} and Viktoriia Zubar and Luigi Cavallo and Magnus Rueping and Osama El-Sepelgy",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: L.M.A thank Universidad de Las Palmas de Gran Canaria (ULPGC) for support. Gratitude is also due to the KAUST for using the supercomputer Shaheen II for providing the computational resources.",

year = "2020",

month = jun,

day = "29",

doi = "10.1039/d0cc02881a",

language = "English (US)",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "ROYAL SOC CHEMISTRY",

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T1 - Racemic alcohols to optically pure amine precursors enabled by catalyst dynamic kinetic resolution: experiment and computation

AU - Azofra, Luis Miguel

AU - Tran, Mai Anh

AU - Zubar, Viktoriia

AU - Cavallo, Luigi

AU - Rueping, Magnus

AU - El-Sepelgy, Osama

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: L.M.A thank Universidad de Las Palmas de Gran Canaria (ULPGC) for support. Gratitude is also due to the KAUST for using the supercomputer Shaheen II for providing the computational resources.

PY - 2020/6/29

Y1 - 2020/6/29

N2 - An unprecedented base metal catalysed asymmetric synthesis of α-chiral amine precursors from racemic alcohols is reported. This redox-neutral reaction utilises a bench-stable manganese complex and Ellman’s sulfinamide as versatile ammonia...

AB - An unprecedented base metal catalysed asymmetric synthesis of α-chiral amine precursors from racemic alcohols is reported. This redox-neutral reaction utilises a bench-stable manganese complex and Ellman’s sulfinamide as versatile ammonia...

UR - http://hdl.handle.net/10754/664013

UR - http://pubs.rsc.org/en/Content/ArticleLanding/2020/CC/D0CC02881A

U2 - 10.1039/d0cc02881a

DO - 10.1039/d0cc02881a

M3 - Article

C2 - 32638725

SN - 1359-7345

JO - Chemical Communications

JF - Chemical Communications

ER -

Racemic alcohols to optically pure amine precursors enabled by catalyst dynamic kinetic resolution: experiment and computation

Abstract

Bibliographical note

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