Quorum Sensing and the Use of Quorum Quenchers as Natural Biocides to Inhibit Sulfate-Reducing Bacteria

Giantommaso Scarascia, Tiannyu Wang, Pei-Ying Hong

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Sulfate-reducing bacteria (SRB) are one of the main protagonist groups of biocorrosion in the seawater environment. Given their principal role in biocorrosion, it remains a crucial task to develop strategies to reduce the abundance of SRBs. Conventional approaches include the use of biocides and antibiotics, which can impose health, safety, and environmental concerns. This review examines an alternative approach to this problem. This is achieved by reviewing the role of quorum sensing (QS) in SRB populations and its impact on the biofilm formation process. Genome databases of SRBs are mined to look for putative QS systems and homologous protein sequences representative of autoinducer receptors or synthases. Subsequently, this review puts forward the potential use of quorum quenchers as natural biocides against SRBs and outlines the potential strategies for the implementation of this approach.
Original languageEnglish (US)
Pages (from-to)39
Issue number4
StatePublished - Dec 15 2016

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledged KAUST grant number(s): BAS/1/1033-01-01
Acknowledgements: The work detailed in this review and the costs to publish in open access are both funded by King Abdullah University of Science and Technology (KAUST) baseline funding BAS/1/1033-01-01 awarded to Pei-Ying Hong. The authors would like to express gratitude to Moustapha Harb for proofreading and editing the review.


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