Prospective multicenter evaluation of the Beckman coulter prostate health index using WHO calibration

Stacy Loeb; Lori J. Sokoll; Dennis L. Broyles; Chris H. Bangma; Ron H.N. Van Schaik; George G. Klee; John T. Wei; Martin G. Sanda; Alan W. Partin; Kevin M. Slawin; Leonard S. Marks; Isaac A. Mizrahi; Sanghyuk S. Shin; Amabelle B. Cruz; Daniel W. Chan; William L. Roberts; William J. Catalona

doi:10.1016/j.juro.2012.11.149

Prospective multicenter evaluation of the Beckman coulter prostate health index using WHO calibration

Stacy Loeb, Lori J. Sokoll, Dennis L. Broyles, Chris H. Bangma, Ron H.N. Van Schaik, George G. Klee, John T. Wei, Martin G. Sanda, Alan W. Partin, Kevin M. Slawin, Leonard S. Marks, Isaac A. Mizrahi, Sanghyuk S. Shin, Amabelle B. Cruz, Daniel W. Chan, William L. Roberts, William J. Catalona

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Purpose: Reported prostate specific antigen values may differ substantially among assays using Hybritech® or WHO standardization. The Beckman Coulter® Prostate Health Index and [-2]proPSA are newly approved serum markers associated with prostate cancer risk and aggressiveness. We studied the influence of assay standardization on these markers. Materials and Methods: Prostate specific antigen, percent free prostate specific antigen and [-2]proPSA were measured using Hybritech calibration in 892 men from a prospective, multicenter study undergoing prostate biopsy. We calculated the Prostate Health Index using the equation, ([-2]proPSA/free prostate specific antigen) × PSA. Index performance characteristics for prostate cancer detection were then determined using recalculated WHO calibration prostate specific antigen values. Results: The median Prostate Health Index was significantly higher in men with prostate cancer than in those with negative biopsies using WHO values (47.4 vs 39.8, p

Original language	English (US)
Pages (from-to)	1702-1706
Number of pages	5
Journal	Journal of Urology
Volume	189
Issue number	5
DOIs	https://doi.org/10.1016/j.juro.2012.11.149
State	Published - May 1 2013
Externally published	Yes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-09-20

ASJC Scopus subject areas

Urology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.juro.2012.11.149

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Loeb, S., Sokoll, L. J., Broyles, D. L., Bangma, C. H., Van Schaik, R. H. N., Klee, G. G., Wei, J. T., Sanda, M. G., Partin, A. W., Slawin, K. M., Marks, L. S., Mizrahi, I. A., Shin, S. S., Cruz, A. B., Chan, D. W., Roberts, W. L., & Catalona, W. J. (2013). Prospective multicenter evaluation of the Beckman coulter prostate health index using WHO calibration. Journal of Urology, 189(5), 1702-1706. https://doi.org/10.1016/j.juro.2012.11.149

@article{5e0519edea604473a9531168548108e0,

title = "Prospective multicenter evaluation of the Beckman coulter prostate health index using WHO calibration",

abstract = "Purpose: Reported prostate specific antigen values may differ substantially among assays using Hybritech{\textregistered} or WHO standardization. The Beckman Coulter{\textregistered} Prostate Health Index and [-2]proPSA are newly approved serum markers associated with prostate cancer risk and aggressiveness. We studied the influence of assay standardization on these markers. Materials and Methods: Prostate specific antigen, percent free prostate specific antigen and [-2]proPSA were measured using Hybritech calibration in 892 men from a prospective, multicenter study undergoing prostate biopsy. We calculated the Prostate Health Index using the equation, ([-2]proPSA/free prostate specific antigen) × PSA. Index performance characteristics for prostate cancer detection were then determined using recalculated WHO calibration prostate specific antigen values. Results: The median Prostate Health Index was significantly higher in men with prostate cancer than in those with negative biopsies using WHO values (47.4 vs 39.8, p",

author = "Stacy Loeb and Sokoll, {Lori J.} and Broyles, {Dennis L.} and Bangma, {Chris H.} and {Van Schaik}, {Ron H.N.} and Klee, {George G.} and Wei, {John T.} and Sanda, {Martin G.} and Partin, {Alan W.} and Slawin, {Kevin M.} and Marks, {Leonard S.} and Mizrahi, {Isaac A.} and Shin, {Sanghyuk S.} and Cruz, {Amabelle B.} and Chan, {Daniel W.} and Roberts, {William L.} and Catalona, {William J.}",

note = "Generated from Scopus record by KAUST IRTS on 2023-09-20",

year = "2013",

month = may,

day = "1",

doi = "10.1016/j.juro.2012.11.149",

language = "English (US)",

volume = "189",

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Loeb, S, Sokoll, LJ, Broyles, DL, Bangma, CH, Van Schaik, RHN, Klee, GG, Wei, JT, Sanda, MG, Partin, AW, Slawin, KM, Marks, LS, Mizrahi, IA, Shin, SS, Cruz, AB, Chan, DW, Roberts, WL & Catalona, WJ 2013, 'Prospective multicenter evaluation of the Beckman coulter prostate health index using WHO calibration', Journal of Urology, vol. 189, no. 5, pp. 1702-1706. https://doi.org/10.1016/j.juro.2012.11.149

TY - JOUR

T1 - Prospective multicenter evaluation of the Beckman coulter prostate health index using WHO calibration

AU - Loeb, Stacy

AU - Sokoll, Lori J.

AU - Broyles, Dennis L.

AU - Bangma, Chris H.

AU - Van Schaik, Ron H.N.

AU - Klee, George G.

AU - Wei, John T.

AU - Sanda, Martin G.

AU - Partin, Alan W.

AU - Slawin, Kevin M.

AU - Marks, Leonard S.

AU - Mizrahi, Isaac A.

AU - Shin, Sanghyuk S.

AU - Cruz, Amabelle B.

AU - Chan, Daniel W.

AU - Roberts, William L.

AU - Catalona, William J.

N1 - Generated from Scopus record by KAUST IRTS on 2023-09-20

PY - 2013/5/1

Y1 - 2013/5/1

N2 - Purpose: Reported prostate specific antigen values may differ substantially among assays using Hybritech® or WHO standardization. The Beckman Coulter® Prostate Health Index and [-2]proPSA are newly approved serum markers associated with prostate cancer risk and aggressiveness. We studied the influence of assay standardization on these markers. Materials and Methods: Prostate specific antigen, percent free prostate specific antigen and [-2]proPSA were measured using Hybritech calibration in 892 men from a prospective, multicenter study undergoing prostate biopsy. We calculated the Prostate Health Index using the equation, ([-2]proPSA/free prostate specific antigen) × PSA. Index performance characteristics for prostate cancer detection were then determined using recalculated WHO calibration prostate specific antigen values. Results: The median Prostate Health Index was significantly higher in men with prostate cancer than in those with negative biopsies using WHO values (47.4 vs 39.8, p

AB - Purpose: Reported prostate specific antigen values may differ substantially among assays using Hybritech® or WHO standardization. The Beckman Coulter® Prostate Health Index and [-2]proPSA are newly approved serum markers associated with prostate cancer risk and aggressiveness. We studied the influence of assay standardization on these markers. Materials and Methods: Prostate specific antigen, percent free prostate specific antigen and [-2]proPSA were measured using Hybritech calibration in 892 men from a prospective, multicenter study undergoing prostate biopsy. We calculated the Prostate Health Index using the equation, ([-2]proPSA/free prostate specific antigen) × PSA. Index performance characteristics for prostate cancer detection were then determined using recalculated WHO calibration prostate specific antigen values. Results: The median Prostate Health Index was significantly higher in men with prostate cancer than in those with negative biopsies using WHO values (47.4 vs 39.8, p

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SP - 1702

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JF - Journal of Urology

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ER -

Prospective multicenter evaluation of the Beckman coulter prostate health index using WHO calibration

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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