Chromatin is the universal template of genetic information in all eukaryotic organisms. Chemical modifications of the DNA-packaging histone proteins and the DNA bases are crucial signaling events in directing the use and readout of eukaryotic genomes. The enzymes that install and remove these chromatin modifications as well as the proteins that bind these marks govern information that goes beyond the sequence of DNA. Therefore, these so-called epigenetic regulators are intensively studied and represent promising drug targets in modern medicine. We summarize and discuss recent advances in the field of chemical biology that have provided chromatin research with sophisticated tools for investigating the composition, activity, and target sites of chromatin modifying enzymes and reader proteins.
Bibliographical noteKAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work was funded by the priority program SPP1623 of the
Deutsche Forschungsgemeinschaft (W.F. and D.S., Grants: FL
1513/3-1 and SCHW 1163/4-1) as well as intramural programs
of the King Abdullah University of Science and Technology
(KAUST) and the Max Planck Society (W.F.).