TY - JOUR
T1 - Preparation of pH-sensitive amphiphilic block star polymers, their self-assembling characteristics and release behavior on encapsulated molecules
AU - Song, Xiaowan
AU - Cao, Ming
AU - Chen, Peng
AU - Xia, Ru
AU - Zheng, Zhengzhi
AU - Miao, Jibin
AU - Yang, Bin
AU - Su, Lifen
AU - Qian, Jiasheng
AU - Feng, Xiaoshuang
N1 - KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: National Natural Science Foundation of China[No.21174001]
PY - 2016/5/28
Y1 - 2016/5/28
N2 - Poly(ethylene glycol) (PEG), a polymer with excellent biocompatibility, was widely used to form nanoparticles for drug delivery applications. In this paper, based on PEG, a series of pH-sensitive amphiphilic block star polymers of poly(ethylene glycol)-block-poly(ethoxy ethyl glycidyl ether) (PEG-b-PEEGE) with different hydrophobic length were synthesized by living anionic ring-opening polymerization method. The products were characterized using 1H NMR and gel permeation chromatography. These copolymers could self-assemble in aqueous solution to form micellar structure with controlled morphologies. Transmission electron microscopy showed that the nanoparticles are spherical or rodlike with different hydrophilic mass fractions. The pH response of polymeric aggregates from PEG-b-PEEGE was detected by fluorescence probe technique at different pH. A pH-dependent release behavior was observed and pH-responsiveness of PEG-b-PEEGE was affected by the hydrophobic block length. These results demonstrated that star-shaped polymers (PEG-b-PEEGE) are attractive candidates as anticancer drug delivery carriers. © 2016 Springer-Verlag Berlin Heidelberg
AB - Poly(ethylene glycol) (PEG), a polymer with excellent biocompatibility, was widely used to form nanoparticles for drug delivery applications. In this paper, based on PEG, a series of pH-sensitive amphiphilic block star polymers of poly(ethylene glycol)-block-poly(ethoxy ethyl glycidyl ether) (PEG-b-PEEGE) with different hydrophobic length were synthesized by living anionic ring-opening polymerization method. The products were characterized using 1H NMR and gel permeation chromatography. These copolymers could self-assemble in aqueous solution to form micellar structure with controlled morphologies. Transmission electron microscopy showed that the nanoparticles are spherical or rodlike with different hydrophilic mass fractions. The pH response of polymeric aggregates from PEG-b-PEEGE was detected by fluorescence probe technique at different pH. A pH-dependent release behavior was observed and pH-responsiveness of PEG-b-PEEGE was affected by the hydrophobic block length. These results demonstrated that star-shaped polymers (PEG-b-PEEGE) are attractive candidates as anticancer drug delivery carriers. © 2016 Springer-Verlag Berlin Heidelberg
UR - http://hdl.handle.net/10754/621572
UR - http://link.springer.com/10.1007/s00289-016-1707-2
UR - http://www.scopus.com/inward/record.url?scp=84971014981&partnerID=8YFLogxK
U2 - 10.1007/s00289-016-1707-2
DO - 10.1007/s00289-016-1707-2
M3 - Article
VL - 74
SP - 183
EP - 194
JO - Polymer Bulletin
JF - Polymer Bulletin
SN - 0170-0839
IS - 1
ER -