Preparation and characterization of spray-dried inhalable powders containing nanoaggregates for pulmonary delivery of anti-tubercular drugs

Ranjot Kaur, Tarun Garg, Umesh Datta Gupta, Pushpa Gupta, Goutam Rath, Amit Kumar Goyal

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

This study aims to prepare spray-dried inhalable powders containing anti-tubercular drugs-loaded HPMC nanoaggregates for sustained delivery of drugs to the lung. Nanoaggregates were prepared by precipitation technique. Results showed that the powders obtained had excellent aerosolization property. High drug encapsulation efficiency was achieved in HPMC nano aggregates, ranging from 60% to 70%. A single pulmonary dose resulted in therapeutic drug concentrations 40% to 60% in the lungs and in other organs (
Original languageEnglish (US)
Pages (from-to)182-187
Number of pages6
JournalArtificial Cells, Nanomedicine and Biotechnology
Volume44
Issue number1
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-10-12

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering
  • Pharmaceutical Science
  • Medicine (miscellaneous)

Fingerprint

Dive into the research topics of 'Preparation and characterization of spray-dried inhalable powders containing nanoaggregates for pulmonary delivery of anti-tubercular drugs'. Together they form a unique fingerprint.

Cite this