Preliminary results on an innovative plasmonic device for macromolecules analysis and sequencing

Marco Francardi; Patrizio Candeloro; Natalia Maria Malara; Francesco T. Gentile; Maria Laura Coluccio; Gerardo Perozziello; Aleesandro Gaggero; Francesco De De Angelis; Enrico Cherubini; Enzo M. Di Fabrizio

doi:10.1016/j.mee.2013.02.096

Preliminary results on an innovative plasmonic device for macromolecules analysis and sequencing

Marco Francardi, Patrizio Candeloro, Natalia Maria Malara, Francesco T. Gentile, Maria Laura Coluccio, Gerardo Perozziello, Aleesandro Gaggero, Francesco De De Angelis, Enrico Cherubini, Enzo M. Di Fabrizio

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

In this work we present the fabrication and theoretical simulation for a new device constituted by a on Substrate Plasmonic Antenna (SPA) combined with a bio-functionalized Atomic Force Microscopy (AFM) cantilever. This device could represent a new strategy to sequence and analyze a single protein or DNA. The idea is to use an SPA composed of an innovative "wedding cake"shaped grating (WCG), in order to excite a Surface Plasmon Polariton (SPP) mode, and a 30-tilted Plasmonic Antenna (PA), able to compress adiabatically the SPP until the tip. The Plasmonic device is placed inside an electrical contact that could be used to unfold protein molecules or DNA. A bio-functionalized AFM tip can be used to fish a single biological element and for alignment with the SPA. Then the unfolded element could be scanned close to the PA and a Tip Enhanced Raman Signal (TERS) can be recorded from the biomolecule. The spatial resolution is limited by the size of the radius of curvature of the antenna, which in this work is about 15 nm, while the vertical scanning is controlled by the piezoelectric of the AFM set up. In this work we demonstrate the possibility to fabricate this innovative plasmonic device and we report FDTD simulations of the innovative WCG. The FDTD simulations show the generation of a plasmonic mode that, coupled with the antenna, give rise to an adiabatic compression which produce an increase of the electric field of about 40 times. © 2013 Elsevier B.V. All rights reserved.

Original language	English (US)
Pages (from-to)	360-364
Number of pages	5
Journal	Microelectronic Engineering
Volume	111
DOIs	https://doi.org/10.1016/j.mee.2013.02.096
State	Published - Nov 2013

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: We gratefully acknowledge financial support from Cariplo Foundation under the project "New Frontiers in Plasmonic Nanosensing" (Grant No. 2011-0338) granted to the nanotechnology laboratory of the Department of Experimental Medicine of the University "Magna Graecia" of Catanzaro.

ASJC Scopus subject areas

Surfaces, Coatings and Films
Atomic and Molecular Physics, and Optics
Electronic, Optical and Magnetic Materials
Electrical and Electronic Engineering
Condensed Matter Physics

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10.1016/j.mee.2013.02.096

Cite this

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title = "Preliminary results on an innovative plasmonic device for macromolecules analysis and sequencing",

abstract = "In this work we present the fabrication and theoretical simulation for a new device constituted by a on Substrate Plasmonic Antenna (SPA) combined with a bio-functionalized Atomic Force Microscopy (AFM) cantilever. This device could represent a new strategy to sequence and analyze a single protein or DNA. The idea is to use an SPA composed of an innovative {"}wedding cake{"}shaped grating (WCG), in order to excite a Surface Plasmon Polariton (SPP) mode, and a 30-tilted Plasmonic Antenna (PA), able to compress adiabatically the SPP until the tip. The Plasmonic device is placed inside an electrical contact that could be used to unfold protein molecules or DNA. A bio-functionalized AFM tip can be used to fish a single biological element and for alignment with the SPA. Then the unfolded element could be scanned close to the PA and a Tip Enhanced Raman Signal (TERS) can be recorded from the biomolecule. The spatial resolution is limited by the size of the radius of curvature of the antenna, which in this work is about 15 nm, while the vertical scanning is controlled by the piezoelectric of the AFM set up. In this work we demonstrate the possibility to fabricate this innovative plasmonic device and we report FDTD simulations of the innovative WCG. The FDTD simulations show the generation of a plasmonic mode that, coupled with the antenna, give rise to an adiabatic compression which produce an increase of the electric field of about 40 times. {\textcopyright} 2013 Elsevier B.V. All rights reserved.",

author = "Marco Francardi and Patrizio Candeloro and Malara, {Natalia Maria} and Gentile, {Francesco T.} and Coluccio, {Maria Laura} and Gerardo Perozziello and Aleesandro Gaggero and {De Angelis}, {Francesco De} and Enrico Cherubini and {Di Fabrizio}, {Enzo M.}",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: We gratefully acknowledge financial support from Cariplo Foundation under the project {"}New Frontiers in Plasmonic Nanosensing{"} (Grant No. 2011-0338) granted to the nanotechnology laboratory of the Department of Experimental Medicine of the University {"}Magna Graecia{"} of Catanzaro.",

year = "2013",

month = nov,

doi = "10.1016/j.mee.2013.02.096",

language = "English (US)",

volume = "111",

pages = "360--364",

journal = "Microelectronic Engineering",

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T1 - Preliminary results on an innovative plasmonic device for macromolecules analysis and sequencing

AU - Francardi, Marco

AU - Candeloro, Patrizio

AU - Malara, Natalia Maria

AU - Gentile, Francesco T.

AU - Coluccio, Maria Laura

AU - Perozziello, Gerardo

AU - Gaggero, Aleesandro

AU - De Angelis, Francesco De

AU - Cherubini, Enrico

AU - Di Fabrizio, Enzo M.

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: We gratefully acknowledge financial support from Cariplo Foundation under the project "New Frontiers in Plasmonic Nanosensing" (Grant No. 2011-0338) granted to the nanotechnology laboratory of the Department of Experimental Medicine of the University "Magna Graecia" of Catanzaro.

PY - 2013/11

Y1 - 2013/11

N2 - In this work we present the fabrication and theoretical simulation for a new device constituted by a on Substrate Plasmonic Antenna (SPA) combined with a bio-functionalized Atomic Force Microscopy (AFM) cantilever. This device could represent a new strategy to sequence and analyze a single protein or DNA. The idea is to use an SPA composed of an innovative "wedding cake"shaped grating (WCG), in order to excite a Surface Plasmon Polariton (SPP) mode, and a 30-tilted Plasmonic Antenna (PA), able to compress adiabatically the SPP until the tip. The Plasmonic device is placed inside an electrical contact that could be used to unfold protein molecules or DNA. A bio-functionalized AFM tip can be used to fish a single biological element and for alignment with the SPA. Then the unfolded element could be scanned close to the PA and a Tip Enhanced Raman Signal (TERS) can be recorded from the biomolecule. The spatial resolution is limited by the size of the radius of curvature of the antenna, which in this work is about 15 nm, while the vertical scanning is controlled by the piezoelectric of the AFM set up. In this work we demonstrate the possibility to fabricate this innovative plasmonic device and we report FDTD simulations of the innovative WCG. The FDTD simulations show the generation of a plasmonic mode that, coupled with the antenna, give rise to an adiabatic compression which produce an increase of the electric field of about 40 times. © 2013 Elsevier B.V. All rights reserved.

AB - In this work we present the fabrication and theoretical simulation for a new device constituted by a on Substrate Plasmonic Antenna (SPA) combined with a bio-functionalized Atomic Force Microscopy (AFM) cantilever. This device could represent a new strategy to sequence and analyze a single protein or DNA. The idea is to use an SPA composed of an innovative "wedding cake"shaped grating (WCG), in order to excite a Surface Plasmon Polariton (SPP) mode, and a 30-tilted Plasmonic Antenna (PA), able to compress adiabatically the SPP until the tip. The Plasmonic device is placed inside an electrical contact that could be used to unfold protein molecules or DNA. A bio-functionalized AFM tip can be used to fish a single biological element and for alignment with the SPA. Then the unfolded element could be scanned close to the PA and a Tip Enhanced Raman Signal (TERS) can be recorded from the biomolecule. The spatial resolution is limited by the size of the radius of curvature of the antenna, which in this work is about 15 nm, while the vertical scanning is controlled by the piezoelectric of the AFM set up. In this work we demonstrate the possibility to fabricate this innovative plasmonic device and we report FDTD simulations of the innovative WCG. The FDTD simulations show the generation of a plasmonic mode that, coupled with the antenna, give rise to an adiabatic compression which produce an increase of the electric field of about 40 times. © 2013 Elsevier B.V. All rights reserved.

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U2 - 10.1016/j.mee.2013.02.096

DO - 10.1016/j.mee.2013.02.096

M3 - Article

SN - 0167-9317

VL - 111

SP - 360

EP - 364

JO - Microelectronic Engineering

JF - Microelectronic Engineering

ER -

Preliminary results on an innovative plasmonic device for macromolecules analysis and sequencing

Abstract

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ASJC Scopus subject areas

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