Prediction of protein aggregation on key proteins involved in ischemic stroke

Rajendran Vijayakumar; Palanisamy Manikandan; Faiz Alfaiz; Mohammad Saleh Al Aboodi; Suresh Mickymaray; Moorthy Kannaiyan; Balaji Bhanoth; Alaguraj Veluchamy

doi:10.1016/j.jksus.2022.102474

Prediction of protein aggregation on key proteins involved in ischemic stroke

Rajendran Vijayakumar, Palanisamy Manikandan, Faiz Alfaiz, Mohammad Saleh Al Aboodi, Suresh Mickymaray, Moorthy Kannaiyan, Balaji Bhanoth, Alaguraj Veluchamy

Biological, Environmental Sciences and Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

Stroke is a genetic condition comprising multiple subtypes and arising from both genic and other multi factors. Genetic basis of stroke is well established through several studies. Advances in integrating sequencing methods and Genome-wide association studies have shown that genetics of stroke is manifested in several genic disorders. Many of the neurodegenerative disorders show aggravated protein aggregation through amyloid formation. Through the protein aggregation prediction, we observed a higher protein disorder in 46 stroke-associated proteins. Also, we observed a large number of aggregation residues distributed as a pattern in multiple regions of these candidate proteins. Overall, we present a study showing that there is a possible interrelationship between protein aggregation and stroke.

Original language	English (US)
Pages (from-to)	102474
Journal	JOURNAL OF KING SAUD UNIVERSITY SCIENCE
Volume	35
Issue number	2
DOIs	https://doi.org/10.1016/j.jksus.2022.102474
State	Published - Dec 10 2022

Bibliographical note

KAUST Repository Item: Exported on 2023-01-24
Acknowledgements: The authors extend their appreciations to the deputyship for Research & Innovation, Ministry of Education in Saudi Arabia for funding this research work through the project number (lFP-2020-38).

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10.1016/j.jksus.2022.102474

https://repository.kaust.edu.sa/bitstream/10754/687277/1/1-s2.0-S1018364722006553-main.pdf

Cite this

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title = "Prediction of protein aggregation on key proteins involved in ischemic stroke",

abstract = "Stroke is a genetic condition comprising multiple subtypes and arising from both genic and other multi factors. Genetic basis of stroke is well established through several studies. Advances in integrating sequencing methods and Genome-wide association studies have shown that genetics of stroke is manifested in several genic disorders. Many of the neurodegenerative disorders show aggravated protein aggregation through amyloid formation. Through the protein aggregation prediction, we observed a higher protein disorder in 46 stroke-associated proteins. Also, we observed a large number of aggregation residues distributed as a pattern in multiple regions of these candidate proteins. Overall, we present a study showing that there is a possible interrelationship between protein aggregation and stroke.",

author = "Rajendran Vijayakumar and Palanisamy Manikandan and Faiz Alfaiz and {Al Aboodi}, {Mohammad Saleh} and Suresh Mickymaray and Moorthy Kannaiyan and Balaji Bhanoth and Alaguraj Veluchamy",

note = "KAUST Repository Item: Exported on 2023-01-24 Acknowledgements: The authors extend their appreciations to the deputyship for Research & Innovation, Ministry of Education in Saudi Arabia for funding this research work through the project number (lFP-2020-38).",

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AU - Vijayakumar, Rajendran

AU - Manikandan, Palanisamy

AU - Alfaiz, Faiz

AU - Al Aboodi, Mohammad Saleh

AU - Mickymaray, Suresh

AU - Kannaiyan, Moorthy

AU - Bhanoth, Balaji

AU - Veluchamy, Alaguraj

N1 - KAUST Repository Item: Exported on 2023-01-24 Acknowledgements: The authors extend their appreciations to the deputyship for Research & Innovation, Ministry of Education in Saudi Arabia for funding this research work through the project number (lFP-2020-38).

PY - 2022/12/10

Y1 - 2022/12/10

N2 - Stroke is a genetic condition comprising multiple subtypes and arising from both genic and other multi factors. Genetic basis of stroke is well established through several studies. Advances in integrating sequencing methods and Genome-wide association studies have shown that genetics of stroke is manifested in several genic disorders. Many of the neurodegenerative disorders show aggravated protein aggregation through amyloid formation. Through the protein aggregation prediction, we observed a higher protein disorder in 46 stroke-associated proteins. Also, we observed a large number of aggregation residues distributed as a pattern in multiple regions of these candidate proteins. Overall, we present a study showing that there is a possible interrelationship between protein aggregation and stroke.

AB - Stroke is a genetic condition comprising multiple subtypes and arising from both genic and other multi factors. Genetic basis of stroke is well established through several studies. Advances in integrating sequencing methods and Genome-wide association studies have shown that genetics of stroke is manifested in several genic disorders. Many of the neurodegenerative disorders show aggravated protein aggregation through amyloid formation. Through the protein aggregation prediction, we observed a higher protein disorder in 46 stroke-associated proteins. Also, we observed a large number of aggregation residues distributed as a pattern in multiple regions of these candidate proteins. Overall, we present a study showing that there is a possible interrelationship between protein aggregation and stroke.

UR - http://hdl.handle.net/10754/687277

UR - https://linkinghub.elsevier.com/retrieve/pii/S1018364722006553

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DO - 10.1016/j.jksus.2022.102474

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JF - JOURNAL OF KING SAUD UNIVERSITY SCIENCE

IS - 2

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Prediction of protein aggregation on key proteins involved in ischemic stroke

Abstract

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