Prediction of protein aggregation on key proteins involved in ischemic stroke

Rajendran Vijayakumar, Palanisamy Manikandan, Faiz Alfaiz, Mohammad Saleh Al Aboodi, Suresh Mickymaray, Moorthy Kannaiyan, Balaji Bhanoth, Alaguraj Veluchamy

Research output: Contribution to journalArticlepeer-review


Stroke is a genetic condition comprising multiple subtypes and arising from both genic and other multi factors. Genetic basis of stroke is well established through several studies. Advances in integrating sequencing methods and Genome-wide association studies have shown that genetics of stroke is manifested in several genic disorders. Many of the neurodegenerative disorders show aggravated protein aggregation through amyloid formation. Through the protein aggregation prediction, we observed a higher protein disorder in 46 stroke-associated proteins. Also, we observed a large number of aggregation residues distributed as a pattern in multiple regions of these candidate proteins. Overall, we present a study showing that there is a possible interrelationship between protein aggregation and stroke.
Original languageEnglish (US)
Pages (from-to)102474
Issue number2
StatePublished - Dec 10 2022

Bibliographical note

KAUST Repository Item: Exported on 2023-01-24
Acknowledgements: The authors extend their appreciations to the deputyship for Research & Innovation, Ministry of Education in Saudi Arabia for funding this research work through the project number (lFP-2020-38).


Dive into the research topics of 'Prediction of protein aggregation on key proteins involved in ischemic stroke'. Together they form a unique fingerprint.

Cite this