Practical and General Palladium-Catalyzed Synthesis of Ketones from Internal Olefins

Bill Morandi, Zachary K. Wickens, Robert H. Grubbs

Research output: Contribution to journalArticlepeer-review

83 Scopus citations


Make it simple! A convenient and general palladium-catalyzed oxidation of internal olefins to ketones is reported. The transformation occurs at room temperature and shows wide substrate scope. Applications to the oxidation of seed-oil derivatives and a bioactive natural product (see scheme) are described, as well as intriguing mechanistic features.
Original languageEnglish (US)
Pages (from-to)3016-3020
Number of pages5
JournalAngewandte Chemie
Issue number10
StatePublished - Jan 16 2013
Externally publishedYes

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: We thank Scott Virgil and the Caltech Center for Catalysis for technical assistance. We gratefully acknowledge financial support from King Abdullah University of Science and Technology Center in Development, King Fahd University of Petroleum and Minerals, the NSF, and the Swiss National Science Foundation for a fellowship to B.M.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.


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