Potential use of SERS-assisted theranostic strategy based on Fe3O4/Au cluster/shell nanocomposites for bio-detection, MRI, and magnetic hyperthermia

Yu Han; Sheng Lan Lei; Jian Hua Lu; Yuan He; Zhi Wei Chen; Lei Ren; Xi Zhou

doi:10.1016/j.msec.2016.03.090

Potential use of SERS-assisted theranostic strategy based on Fe₃O₄/Au cluster/shell nanocomposites for bio-detection, MRI, and magnetic hyperthermia

Yu Han, Sheng Lan Lei, Jian Hua Lu, Yuan He, Zhi Wei Chen^*, Lei Ren, Xi Zhou

^*Corresponding author for this work

Physical Sciences and Engineering

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

A surface-enhanced Raman scattering (SERS)-assisted theranostic strategy was designed based on a synthesized multifunctional Fe₃O₄/Au cluster/shell nanocomposite. This theranostic strategy was used for free prostate specific antigen (free-PSA) detection, magnetic resonance imaging (MRI), and magnetic hyperthermia. The lowest protein concentration detected was 1 ng mL^{- 1}, and the limit of detection (LOD) of the calculated PSA was 0.75 ng mL^{- 1}. Then, MRI was carried out to visualize the tumor cell. Lastly, magnetic hyperthermia was employed and revealed a favorable killing effect for the tumor cells. Thus, this SERS-assisted strategy based on a Fe₃O₄/Au cluster/shell nanocomposite showed great advantages in theranostic treatment.

Original language	English (US)
Pages (from-to)	199-207
Number of pages	9
Journal	Materials Science and Engineering C
Volume	64
DOIs	https://doi.org/10.1016/j.msec.2016.03.090
State	Published - Jul 1 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier B.V. All rights reserved.

Keywords

FeO@Au nanoparticles
MRI
Magnetic hyperthermia
Multifunction
PSA detection
SERS

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/j.msec.2016.03.090

Cite this

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title = "Potential use of SERS-assisted theranostic strategy based on Fe3O4/Au cluster/shell nanocomposites for bio-detection, MRI, and magnetic hyperthermia",

abstract = "A surface-enhanced Raman scattering (SERS)-assisted theranostic strategy was designed based on a synthesized multifunctional Fe3O4/Au cluster/shell nanocomposite. This theranostic strategy was used for free prostate specific antigen (free-PSA) detection, magnetic resonance imaging (MRI), and magnetic hyperthermia. The lowest protein concentration detected was 1 ng mL- 1, and the limit of detection (LOD) of the calculated PSA was 0.75 ng mL- 1. Then, MRI was carried out to visualize the tumor cell. Lastly, magnetic hyperthermia was employed and revealed a favorable killing effect for the tumor cells. Thus, this SERS-assisted strategy based on a Fe3O4/Au cluster/shell nanocomposite showed great advantages in theranostic treatment.",

keywords = "FeO@Au nanoparticles, MRI, Magnetic hyperthermia, Multifunction, PSA detection, SERS",

author = "Yu Han and Lei, {Sheng Lan} and Lu, {Jian Hua} and Yuan He and Chen, {Zhi Wei} and Lei Ren and Xi Zhou",

year = "2016",

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AU - Lei, Sheng Lan

AU - Lu, Jian Hua

AU - He, Yuan

AU - Chen, Zhi Wei

AU - Ren, Lei

AU - Zhou, Xi

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