Potential use of SERS-assisted theranostic strategy based on Fe3O4/Au cluster/shell nanocomposites for bio-detection, MRI, and magnetic hyperthermia

Yu Han, Sheng Lan Lei, Jian Hua Lu, Yuan He, Zhi Wei Chen*, Lei Ren, Xi Zhou

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

A surface-enhanced Raman scattering (SERS)-assisted theranostic strategy was designed based on a synthesized multifunctional Fe3O4/Au cluster/shell nanocomposite. This theranostic strategy was used for free prostate specific antigen (free-PSA) detection, magnetic resonance imaging (MRI), and magnetic hyperthermia. The lowest protein concentration detected was 1 ng mL- 1, and the limit of detection (LOD) of the calculated PSA was 0.75 ng mL- 1. Then, MRI was carried out to visualize the tumor cell. Lastly, magnetic hyperthermia was employed and revealed a favorable killing effect for the tumor cells. Thus, this SERS-assisted strategy based on a Fe3O4/Au cluster/shell nanocomposite showed great advantages in theranostic treatment.

Original languageEnglish (US)
Pages (from-to)199-207
Number of pages9
JournalMaterials Science and Engineering C
Volume64
DOIs
StatePublished - Jul 1 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier B.V. All rights reserved.

Keywords

  • FeO@Au nanoparticles
  • MRI
  • Magnetic hyperthermia
  • Multifunction
  • PSA detection
  • SERS

ASJC Scopus subject areas

  • General Medicine

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