Potent antifouling compounds produced by marine Streptomyces

Ying Xu, Hongping He, Stefan Schulz, Xin Liu, Nobushino Fusetani, Hairong Xiong, Xiang Xiao, Pei-Yuan Qian

Research output: Contribution to journalArticlepeer-review

137 Scopus citations


Biofouling causes huge economic loss and a recent global ban on organotin compounds as antifouling agents has increased the need for safe and effective antifouling compounds. Five structurally similar compounds were isolated from the crude extract of a marine Streptomyces strain obtained from deep-sea sediments. Antifouling activities of these five compounds and four other structurally-related compounds isolated from a North Sea Streptomyces strain against major fouling organisms were compared to probe structure-activity relationships of compounds. The functional moiety responsible for antifouling activity lies in the 2-furanone ring and that the lipophilicity of compounds substantially affects their antifouling activities. Based on these findings, a compound with a straight alkyl side-chain was synthesized and proved itself as a very effective non-toxic, anti-larval settlement agent against three major fouling organisms. The strong antifouling activity, relatively low toxicity, and simple structures of these compounds make them promising candidates for new antifouling additives. © 2009 Elsevier Ltd. All rights reserved.
Original languageEnglish (US)
Pages (from-to)1331-1336
Number of pages6
JournalBioresource Technology
Issue number4
StatePublished - Feb 2010

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work was supported by a Grant from China Ocean Mineral Resources Research and Development Association (COMRRDA06/07.Sc02), a RGC Grant (HKUST6418/06M) from the Hong Kong SAR, and a Grant from the King Abdullah University of Science & Technology Global Special Academic Partnership Program (KAUST003-CML.07/08) to PY Qjan.

ASJC Scopus subject areas

  • Bioengineering
  • Environmental Engineering
  • Waste Management and Disposal


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