Post-translational modulation of pluripotency

Ning Cai; Mo Li; Jing Qu; Guang Hui Liu; Juan Carlos Izpisua Belmonte

doi:10.1093/jmcb/mjs031

Post-translational modulation of pluripotency

Ning Cai, Mo Li, Jing Qu, Guang Hui Liu^*, Juan Carlos Izpisua Belmonte

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

43 Scopus citations

Abstract

The maintenance of pluripotency relies on an intricate transcriptional network hinged on a key set of transcription factors. Pluripotent stem cells have been shown to be sensitive to modulations of the cellular abundance and transcriptional activity of these key pluripotency factors. Recent evidence highlights the important role of post-translational modifications, including ubiquitination, sumoylation, phosphorylation, methylation, and acetylation, in regulating the levels and activity of pluripotency factors to achieve a balance between pluripotency and differentiation.

Original language	English (US)
Pages (from-to)	262-265
Number of pages	4
Journal	Journal of Molecular Cell Biology
Volume	4
Issue number	4
DOIs	https://doi.org/10.1093/jmcb/mjs031
State	Published - Aug 2012
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1093/jmcb/mjs031

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title = "Post-translational modulation of pluripotency",

abstract = "The maintenance of pluripotency relies on an intricate transcriptional network hinged on a key set of transcription factors. Pluripotent stem cells have been shown to be sensitive to modulations of the cellular abundance and transcriptional activity of these key pluripotency factors. Recent evidence highlights the important role of post-translational modifications, including ubiquitination, sumoylation, phosphorylation, methylation, and acetylation, in regulating the levels and activity of pluripotency factors to achieve a balance between pluripotency and differentiation.",

author = "Ning Cai and Mo Li and Jing Qu and Liu, {Guang Hui} and {Izpisua Belmonte}, {Juan Carlos}",

year = "2012",

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AU - Cai, Ning

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AU - Qu, Jing

AU - Liu, Guang Hui

AU - Izpisua Belmonte, Juan Carlos

PY - 2012/8

Y1 - 2012/8

N2 - The maintenance of pluripotency relies on an intricate transcriptional network hinged on a key set of transcription factors. Pluripotent stem cells have been shown to be sensitive to modulations of the cellular abundance and transcriptional activity of these key pluripotency factors. Recent evidence highlights the important role of post-translational modifications, including ubiquitination, sumoylation, phosphorylation, methylation, and acetylation, in regulating the levels and activity of pluripotency factors to achieve a balance between pluripotency and differentiation.

AB - The maintenance of pluripotency relies on an intricate transcriptional network hinged on a key set of transcription factors. Pluripotent stem cells have been shown to be sensitive to modulations of the cellular abundance and transcriptional activity of these key pluripotency factors. Recent evidence highlights the important role of post-translational modifications, including ubiquitination, sumoylation, phosphorylation, methylation, and acetylation, in regulating the levels and activity of pluripotency factors to achieve a balance between pluripotency and differentiation.

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U2 - 10.1093/jmcb/mjs031

DO - 10.1093/jmcb/mjs031

M3 - Review article

C2 - 22679102

AN - SCOPUS:84864859773

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SP - 262

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ER -

Post-translational modulation of pluripotency

Abstract

ASJC Scopus subject areas

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