Porous silicon as drug carrier for controlled delivery of doxorubicin anticancer agent

Lisa Vaccari; Davide Canton; Nadia Zaffaroni; Raffaella Villa; Massimo Tormen; Enzo di Fabrizio

doi:10.1016/j.mee.2006.01.113

Porous silicon as drug carrier for controlled delivery of doxorubicin anticancer agent

Lisa Vaccari^*, Davide Canton, Nadia Zaffaroni, Raffaella Villa, Massimo Tormen, Enzo di Fabrizio

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

121 Scopus citations

Abstract

One of the topics of the biomedical research is to design and develop new drug delivery systems able to perform time-controlled release of medicals with target specificity. Porous silicon, characterized by macropores of 2 μm average diameter, with a 200 nm thick nanoporous coverage, was produced and its potential applications as drug-carrier were investigated. Doxorubicin loaded porous silicon bits exhibited a time-depending drug delivery profile that is in trend with the cytotoxicity of adenocarcinoma cancer cells exposed to bits.

Original language	English (US)
Pages (from-to)	1598-1601
Number of pages	4
Journal	Microelectronic Engineering
Volume	83
Issue number	4-9 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.mee.2006.01.113
State	Published - Apr 2006
Externally published	Yes

Keywords

Controlled Drug Delivery
Doxorubicin
Porous Silicon
Post-surgical Chemotherapy

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Surfaces, Coatings and Films
Atomic and Molecular Physics, and Optics
Electrical and Electronic Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.mee.2006.01.113

Cite this

@article{1722a9a5441e4aa2b22ea4358e961810,

title = "Porous silicon as drug carrier for controlled delivery of doxorubicin anticancer agent",

abstract = "One of the topics of the biomedical research is to design and develop new drug delivery systems able to perform time-controlled release of medicals with target specificity. Porous silicon, characterized by macropores of 2 μm average diameter, with a 200 nm thick nanoporous coverage, was produced and its potential applications as drug-carrier were investigated. Doxorubicin loaded porous silicon bits exhibited a time-depending drug delivery profile that is in trend with the cytotoxicity of adenocarcinoma cancer cells exposed to bits.",

keywords = "Controlled Drug Delivery, Doxorubicin, Porous Silicon, Post-surgical Chemotherapy",

author = "Lisa Vaccari and Davide Canton and Nadia Zaffaroni and Raffaella Villa and Massimo Tormen and {di Fabrizio}, Enzo",

year = "2006",

month = apr,

doi = "10.1016/j.mee.2006.01.113",

language = "English (US)",

volume = "83",

pages = "1598--1601",

journal = "Microelectronic Engineering",

issn = "0167-9317",

publisher = "ELSEVIER SCIENCE BV",

number = "4-9 SPEC. ISS.",

}

TY - JOUR

T1 - Porous silicon as drug carrier for controlled delivery of doxorubicin anticancer agent

AU - Vaccari, Lisa

AU - Canton, Davide

AU - Zaffaroni, Nadia

AU - Villa, Raffaella

AU - Tormen, Massimo

AU - di Fabrizio, Enzo

PY - 2006/4

Y1 - 2006/4

N2 - One of the topics of the biomedical research is to design and develop new drug delivery systems able to perform time-controlled release of medicals with target specificity. Porous silicon, characterized by macropores of 2 μm average diameter, with a 200 nm thick nanoporous coverage, was produced and its potential applications as drug-carrier were investigated. Doxorubicin loaded porous silicon bits exhibited a time-depending drug delivery profile that is in trend with the cytotoxicity of adenocarcinoma cancer cells exposed to bits.

AB - One of the topics of the biomedical research is to design and develop new drug delivery systems able to perform time-controlled release of medicals with target specificity. Porous silicon, characterized by macropores of 2 μm average diameter, with a 200 nm thick nanoporous coverage, was produced and its potential applications as drug-carrier were investigated. Doxorubicin loaded porous silicon bits exhibited a time-depending drug delivery profile that is in trend with the cytotoxicity of adenocarcinoma cancer cells exposed to bits.

KW - Controlled Drug Delivery

KW - Doxorubicin

KW - Porous Silicon

KW - Post-surgical Chemotherapy

UR - http://www.scopus.com/inward/record.url?scp=33646057408&partnerID=8YFLogxK

U2 - 10.1016/j.mee.2006.01.113

DO - 10.1016/j.mee.2006.01.113

M3 - Article

AN - SCOPUS:33646057408

SN - 0167-9317

VL - 83

SP - 1598

EP - 1601

JO - Microelectronic Engineering

JF - Microelectronic Engineering

IS - 4-9 SPEC. ISS.

ER -

Porous silicon as drug carrier for controlled delivery of doxorubicin anticancer agent

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this