Polyoxometalate-cyclodextrin supramolecular entities for real-time in situ monitoring of dopamine released from neuroblastoma cells

Saptami Suresh Shetty, Basem Moosa, Li Zhang, Buthainah Alshankiti, Walaa Baslyman, Veerappan Mani*, Niveen M. Khashab*, Khaled Nabil Salama*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Optimized and sensitive biomarker detection has recently been shown to have a critical impact on quality of diagnosis and medical care options. In this research study, polyoxometalate-γ-cyclodextrin metal−organic framework (POM–γCD MOF) was utilized as an electrocatalyst to fabricate highly selective sensors to detect in-situ released dopamine. The POM–γCD MOF produced multiple modes of signals for dopamine including electrochemical, colorimetric, and smartphone read-outs. Real-time quantitative monitoring of SH-SY5Y neuroblastoma cellular dopamine production was successfully demonstrated under various stimuli at different time intervals. The POM-CD MOF sensor and linear regression model were used to develop a smartphone read-out platform, which converts dopamine visual signals to digital signals within a few seconds. Ultimately, POM–γCD MOFs can play a significant role in the diagnosis and treatment of various diseases that involve dopamine as a significant biomarker.

Original languageEnglish (US)
Article number115240
JournalBiosensors and Bioelectronics
StatePublished - Jun 1 2023

Bibliographical note

Funding Information:
The authors acknowledge the financial support from King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia and funding from the KAUST smart health initiative .

Publisher Copyright:
© 2023 Elsevier B.V.


  • In situ dopamine monitoring
  • Metal organic frameworks
  • Neurodegenerative disease
  • Point-of-care sensors
  • Real-time sensors
  • Supramolecular entities

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry


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