Polyoxometalate-cyclodextrin supramolecular entities for real-time in situ monitoring of dopamine released from neuroblastoma cells

Saptami Suresh Shetty; Basem Moosa; Li Zhang; Buthainah Alshankiti; Walaa Baslyman; Veerappan Mani; Niveen M. Khashab; Khaled Nabil Salama

doi:10.1016/j.bios.2023.115240

Polyoxometalate-cyclodextrin supramolecular entities for real-time in situ monitoring of dopamine released from neuroblastoma cells

Saptami Suresh Shetty, Basem Moosa, Li Zhang, Buthainah Alshankiti, Walaa Baslyman, Veerappan Mani^*, Niveen M. Khashab^*, Khaled Nabil Salama^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Optimized and sensitive biomarker detection has recently been shown to have a critical impact on quality of diagnosis and medical care options. In this research study, polyoxometalate-γ-cyclodextrin metal−organic framework (POM–γCD MOF) was utilized as an electrocatalyst to fabricate highly selective sensors to detect in-situ released dopamine. The POM–γCD MOF produced multiple modes of signals for dopamine including electrochemical, colorimetric, and smartphone read-outs. Real-time quantitative monitoring of SH-SY5Y neuroblastoma cellular dopamine production was successfully demonstrated under various stimuli at different time intervals. The POM-CD MOF sensor and linear regression model were used to develop a smartphone read-out platform, which converts dopamine visual signals to digital signals within a few seconds. Ultimately, POM–γCD MOFs can play a significant role in the diagnosis and treatment of various diseases that involve dopamine as a significant biomarker.

Original language	English (US)
Article number	115240
Journal	Biosensors and Bioelectronics
Volume	229
DOIs	https://doi.org/10.1016/j.bios.2023.115240
State	Published - Jun 1 2023

Bibliographical note

Funding Information:
The authors acknowledge the financial support from King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia and funding from the KAUST smart health initiative .

Publisher Copyright:
© 2023 Elsevier B.V.

Keywords

In situ dopamine monitoring
Metal organic frameworks
Neurodegenerative disease
Point-of-care sensors
Real-time sensors
Supramolecular entities

ASJC Scopus subject areas

Biotechnology
Biophysics
Biomedical Engineering
Electrochemistry

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10.1016/j.bios.2023.115240

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title = "Polyoxometalate-cyclodextrin supramolecular entities for real-time in situ monitoring of dopamine released from neuroblastoma cells",

abstract = "Optimized and sensitive biomarker detection has recently been shown to have a critical impact on quality of diagnosis and medical care options. In this research study, polyoxometalate-γ-cyclodextrin metal−organic framework (POM–γCD MOF) was utilized as an electrocatalyst to fabricate highly selective sensors to detect in-situ released dopamine. The POM–γCD MOF produced multiple modes of signals for dopamine including electrochemical, colorimetric, and smartphone read-outs. Real-time quantitative monitoring of SH-SY5Y neuroblastoma cellular dopamine production was successfully demonstrated under various stimuli at different time intervals. The POM-CD MOF sensor and linear regression model were used to develop a smartphone read-out platform, which converts dopamine visual signals to digital signals within a few seconds. Ultimately, POM–γCD MOFs can play a significant role in the diagnosis and treatment of various diseases that involve dopamine as a significant biomarker.",

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note = "Funding Information: The authors acknowledge the financial support from King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia and funding from the KAUST smart health initiative . Publisher Copyright: {\textcopyright} 2023 Elsevier B.V.",

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AU - Zhang, Li

AU - Alshankiti, Buthainah

AU - Baslyman, Walaa

AU - Mani, Veerappan

AU - Khashab, Niveen M.

AU - Salama, Khaled Nabil

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N2 - Optimized and sensitive biomarker detection has recently been shown to have a critical impact on quality of diagnosis and medical care options. In this research study, polyoxometalate-γ-cyclodextrin metal−organic framework (POM–γCD MOF) was utilized as an electrocatalyst to fabricate highly selective sensors to detect in-situ released dopamine. The POM–γCD MOF produced multiple modes of signals for dopamine including electrochemical, colorimetric, and smartphone read-outs. Real-time quantitative monitoring of SH-SY5Y neuroblastoma cellular dopamine production was successfully demonstrated under various stimuli at different time intervals. The POM-CD MOF sensor and linear regression model were used to develop a smartphone read-out platform, which converts dopamine visual signals to digital signals within a few seconds. Ultimately, POM–γCD MOFs can play a significant role in the diagnosis and treatment of various diseases that involve dopamine as a significant biomarker.

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Polyoxometalate-cyclodextrin supramolecular entities for real-time in situ monitoring of dopamine released from neuroblastoma cells

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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