Polymorphisms in Isoniazid and Prothionamide Resistance Genes of the Mycobacterium tuberculosis Complex

M. Projahn, C. U. Koser, S. Homolka, D. K. Summers, John A.C. Archer, S. Niemann

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Sequence analyses of 74 strains that encompassed major phylogenetic lineages of the Mycobacterium tuberculosis complex revealed 10 polymorphisms in mshA (Rv0486) and four polymorphisms in inhA (Rv1484) that were not responsible for isoniazid or prothionamide resistance. Instead, some of these mutations were phylogenetically informative. This genetic diversity must be taken into consideration for drug development and for the design of molecular tests for drug resistance.
Original languageEnglish (US)
Pages (from-to)4408-4411
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Issue number9
StatePublished - Jun 27 2011

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