TY - JOUR
T1 - Poly(DL-lactide)-b-poly(N,N-dimethylamino-2-ethyl methacrylate)
T2 - Synthesis, characterization, micellization behavior in aqueous solutions, and encapsulation of the hydrophobic drug dipyridamole
AU - Karanikolopoulos, Nikos
AU - Zamurovic, Miljana
AU - Pitsikalis, Marinos
AU - Hadjichristidis, Nikos
PY - 2010/2/8
Y1 - 2010/2/8
N2 - We synthesized a series of well-defined poly(DL-lactide)-b-poly(N,N- dimethylamino-2-ethyl methacrylate) (PDLLAb-PDMAEMA) amphiphilic diblock copolymers by employing a three-step procedure: (a) ring-opening polymerization (ROP) of DL-lactide using n-decanol and stannous octoate, Sn(Oct)2, as the initiating system, (b) reaction of the PDLLA hydroxyl end groups with bromoisobutyryl bromide, and (c) atom transfer radical polymerization, ATRP, of DMAEMA with the newly created bromoisobutyryl initiating site. The aggregation behavior of the prepared block copolymers was investigated by dynamic light scattering and ζ potential measurements at 25 °C in aqueous solutions of different pH values. The hydrophobic drug dipyridamole was efficiently incorporated into the copolymer aggregates in aqueous solutions of pH 7.40. High partition coefficient values were determined by fluorescence spectroscopy.
AB - We synthesized a series of well-defined poly(DL-lactide)-b-poly(N,N- dimethylamino-2-ethyl methacrylate) (PDLLAb-PDMAEMA) amphiphilic diblock copolymers by employing a three-step procedure: (a) ring-opening polymerization (ROP) of DL-lactide using n-decanol and stannous octoate, Sn(Oct)2, as the initiating system, (b) reaction of the PDLLA hydroxyl end groups with bromoisobutyryl bromide, and (c) atom transfer radical polymerization, ATRP, of DMAEMA with the newly created bromoisobutyryl initiating site. The aggregation behavior of the prepared block copolymers was investigated by dynamic light scattering and ζ potential measurements at 25 °C in aqueous solutions of different pH values. The hydrophobic drug dipyridamole was efficiently incorporated into the copolymer aggregates in aqueous solutions of pH 7.40. High partition coefficient values were determined by fluorescence spectroscopy.
UR - http://www.scopus.com/inward/record.url?scp=76249095948&partnerID=8YFLogxK
U2 - 10.1021/bm901151g
DO - 10.1021/bm901151g
M3 - Article
C2 - 20041661
AN - SCOPUS:76249095948
SN - 1525-7797
VL - 11
SP - 430
EP - 438
JO - Biomacromolecules
JF - Biomacromolecules
IS - 2
ER -