Polycomb complex recruitment in pluripotent stem cells

Maria J. Barrero; Juan Carlos Izpisua Belmonte

doi:10.1038/ncb2723

Polycomb complex recruitment in pluripotent stem cells

Maria J. Barrero^*, Juan Carlos Izpisua Belmonte

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The recruitment of the silencing complex Polycomb group (PcG) to its target sites in mammalian cells has remained elusive. A prevalent model proposes that the PRC1 component is recruited through recognition of methylated H3K27 found at target sites occupied by the PRC2 component. However, mounting evidence suggests that PRC2-independent mechanisms of PRC1 recruitment exist. Three studies describe that the histone demethylase Kdm2b binds to unmethylated CpG islands and recruits a subset of PRC1 complexes to chromatin in pluripotent stem cells.

Original language	English (US)
Pages (from-to)	348-350
Number of pages	3
Journal	Nature Cell Biology
Volume	15
Issue number	4
DOIs	https://doi.org/10.1038/ncb2723
State	Published - Apr 2013
Externally published	Yes

ASJC Scopus subject areas

Cell Biology

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title = "Polycomb complex recruitment in pluripotent stem cells",

abstract = "The recruitment of the silencing complex Polycomb group (PcG) to its target sites in mammalian cells has remained elusive. A prevalent model proposes that the PRC1 component is recruited through recognition of methylated H3K27 found at target sites occupied by the PRC2 component. However, mounting evidence suggests that PRC2-independent mechanisms of PRC1 recruitment exist. Three studies describe that the histone demethylase Kdm2b binds to unmethylated CpG islands and recruits a subset of PRC1 complexes to chromatin in pluripotent stem cells.",

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AB - The recruitment of the silencing complex Polycomb group (PcG) to its target sites in mammalian cells has remained elusive. A prevalent model proposes that the PRC1 component is recruited through recognition of methylated H3K27 found at target sites occupied by the PRC2 component. However, mounting evidence suggests that PRC2-independent mechanisms of PRC1 recruitment exist. Three studies describe that the histone demethylase Kdm2b binds to unmethylated CpG islands and recruits a subset of PRC1 complexes to chromatin in pluripotent stem cells.

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Polycomb complex recruitment in pluripotent stem cells

Abstract

ASJC Scopus subject areas

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