Poly(amino ester)s as an emerging synthetic biodegradable polymer platform: Recent developments and future trends

Xin Wang; Zhengbiao Zhang; Nikos Hadjichristidis

doi:10.1016/j.progpolymsci.2022.101634

Poly(amino ester)s as an emerging synthetic biodegradable polymer platform: Recent developments and future trends

Xin Wang, Zhengbiao Zhang, Nikos Hadjichristidis

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Poly(amino ester)s (PAEs) refer to a class of synthetic polymers characterized by repeating units in the backbone having tertiary amines and ester bonds, and bringing together the inherent biodegradability of polyesters and the rich tunable functionalities provided by tertiary amines. The presence of tertiary amines allows the introduction of various pendant groups, leading to diverse PAE material and properties, such as biodegradability, biocompatibility, water-solubility, stimulus-responsiveness (pH or temperature), etc. To date, PAEs are evolving into a new class of biodegradable polymer materials independent of aliphatic polyesters and have been widely used in various biomedical fields, such as gene delivery, drug delivery, bioimaging agents, etc. In addition, a new family of PAEs, namely N-acylated PAEs, with the same pendant carbonyl groups as poly(2-oxazoline)s, is expected to develop into new biopolymer platforms similar to polypeptoids and polyoxazolines. This review comprehensively summarizes the synthesis methods of PAEs, including polycondensation (PCD), Michael addition polymerization (MAP), spontaneous zwitterionic copolymerization (SZWIP), and ring-opening polymerization (ROP).

Original language	English (US)
Pages (from-to)	101634
Journal	Progress in Polymer Science
Volume	136
DOIs	https://doi.org/10.1016/j.progpolymsci.2022.101634
State	Published - Nov 24 2022

Bibliographical note

KAUST Repository Item: Exported on 2022-12-02
Acknowledgements: This work was supported by the National Outstanding Youth Foundation of China (21925107), the National Key R&D Program of China (2022YFB3704900, 2020YFA0710700), the Collaborative Innovation Center of Suzhou Nano Science and Technology, the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) and the Program of Innovative Research Team of Soochow University. N. H. acknowledges the support of King Abdullah University of Science and Technology.

ASJC Scopus subject areas

Materials Chemistry
Organic Chemistry
Polymers and Plastics
Ceramics and Composites
Surfaces and Interfaces

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10.1016/j.progpolymsci.2022.101634

https://repository.kaust.edu.sa/bitstream/10754/686069/1/1-s2.0-S0079670022001320-main-online_removed.pdf

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title = "Poly(amino ester)s as an emerging synthetic biodegradable polymer platform: Recent developments and future trends",

abstract = "Poly(amino ester)s (PAEs) refer to a class of synthetic polymers characterized by repeating units in the backbone having tertiary amines and ester bonds, and bringing together the inherent biodegradability of polyesters and the rich tunable functionalities provided by tertiary amines. The presence of tertiary amines allows the introduction of various pendant groups, leading to diverse PAE material and properties, such as biodegradability, biocompatibility, water-solubility, stimulus-responsiveness (pH or temperature), etc. To date, PAEs are evolving into a new class of biodegradable polymer materials independent of aliphatic polyesters and have been widely used in various biomedical fields, such as gene delivery, drug delivery, bioimaging agents, etc. In addition, a new family of PAEs, namely N-acylated PAEs, with the same pendant carbonyl groups as poly(2-oxazoline)s, is expected to develop into new biopolymer platforms similar to polypeptoids and polyoxazolines. This review comprehensively summarizes the synthesis methods of PAEs, including polycondensation (PCD), Michael addition polymerization (MAP), spontaneous zwitterionic copolymerization (SZWIP), and ring-opening polymerization (ROP).",

author = "Xin Wang and Zhengbiao Zhang and Nikos Hadjichristidis",

note = "KAUST Repository Item: Exported on 2022-12-02 Acknowledgements: This work was supported by the National Outstanding Youth Foundation of China (21925107), the National Key R&D Program of China (2022YFB3704900, 2020YFA0710700), the Collaborative Innovation Center of Suzhou Nano Science and Technology, the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) and the Program of Innovative Research Team of Soochow University. N. H. acknowledges the support of King Abdullah University of Science and Technology.",

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AU - Wang, Xin

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AU - Hadjichristidis, Nikos

N1 - KAUST Repository Item: Exported on 2022-12-02 Acknowledgements: This work was supported by the National Outstanding Youth Foundation of China (21925107), the National Key R&D Program of China (2022YFB3704900, 2020YFA0710700), the Collaborative Innovation Center of Suzhou Nano Science and Technology, the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) and the Program of Innovative Research Team of Soochow University. N. H. acknowledges the support of King Abdullah University of Science and Technology.

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N2 - Poly(amino ester)s (PAEs) refer to a class of synthetic polymers characterized by repeating units in the backbone having tertiary amines and ester bonds, and bringing together the inherent biodegradability of polyesters and the rich tunable functionalities provided by tertiary amines. The presence of tertiary amines allows the introduction of various pendant groups, leading to diverse PAE material and properties, such as biodegradability, biocompatibility, water-solubility, stimulus-responsiveness (pH or temperature), etc. To date, PAEs are evolving into a new class of biodegradable polymer materials independent of aliphatic polyesters and have been widely used in various biomedical fields, such as gene delivery, drug delivery, bioimaging agents, etc. In addition, a new family of PAEs, namely N-acylated PAEs, with the same pendant carbonyl groups as poly(2-oxazoline)s, is expected to develop into new biopolymer platforms similar to polypeptoids and polyoxazolines. This review comprehensively summarizes the synthesis methods of PAEs, including polycondensation (PCD), Michael addition polymerization (MAP), spontaneous zwitterionic copolymerization (SZWIP), and ring-opening polymerization (ROP).

AB - Poly(amino ester)s (PAEs) refer to a class of synthetic polymers characterized by repeating units in the backbone having tertiary amines and ester bonds, and bringing together the inherent biodegradability of polyesters and the rich tunable functionalities provided by tertiary amines. The presence of tertiary amines allows the introduction of various pendant groups, leading to diverse PAE material and properties, such as biodegradability, biocompatibility, water-solubility, stimulus-responsiveness (pH or temperature), etc. To date, PAEs are evolving into a new class of biodegradable polymer materials independent of aliphatic polyesters and have been widely used in various biomedical fields, such as gene delivery, drug delivery, bioimaging agents, etc. In addition, a new family of PAEs, namely N-acylated PAEs, with the same pendant carbonyl groups as poly(2-oxazoline)s, is expected to develop into new biopolymer platforms similar to polypeptoids and polyoxazolines. This review comprehensively summarizes the synthesis methods of PAEs, including polycondensation (PCD), Michael addition polymerization (MAP), spontaneous zwitterionic copolymerization (SZWIP), and ring-opening polymerization (ROP).

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JO - Progress in Polymer Science

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ER -

Poly(amino ester)s as an emerging synthetic biodegradable polymer platform: Recent developments and future trends

Abstract

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