Polarity-directed one-pot asymmetric cascade reactions mediated by two catalysts in an aqueous buffer

Steven T. Scroggins; Yonggui Chi; Jean M.J. Fréchet

doi:10.1002/anie.200902945

Polarity-directed one-pot asymmetric cascade reactions mediated by two catalysts in an aqueous buffer

Steven T. Scroggins, Yonggui Chi, Jean M.J. Fréchet

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

(Figure Presented) A crossing between phases: Polarity makes a difference in distinguishing substrates of otherwise nearly identical chemical reactivities. A one-pot cascade reaction involving nitromethane and two aliphatic aldehydes with similar reactivities has been developed (see scheme). The use of a biphasic reaction medium with two different organic catalysts results in the controlled incorporation of both aldehyde substrates into a single major cross-product.

Original language	English (US)
Pages (from-to)	2393-2396
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	13
DOIs	https://doi.org/10.1002/anie.200902945
State	Published - Mar 22 2010
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200902945

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title = "Polarity-directed one-pot asymmetric cascade reactions mediated by two catalysts in an aqueous buffer",

abstract = "(Figure Presented) A crossing between phases: Polarity makes a difference in distinguishing substrates of otherwise nearly identical chemical reactivities. A one-pot cascade reaction involving nitromethane and two aliphatic aldehydes with similar reactivities has been developed (see scheme). The use of a biphasic reaction medium with two different organic catalysts results in the controlled incorporation of both aldehyde substrates into a single major cross-product.",

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AU - Chi, Yonggui

AU - Fréchet, Jean M.J.

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N2 - (Figure Presented) A crossing between phases: Polarity makes a difference in distinguishing substrates of otherwise nearly identical chemical reactivities. A one-pot cascade reaction involving nitromethane and two aliphatic aldehydes with similar reactivities has been developed (see scheme). The use of a biphasic reaction medium with two different organic catalysts results in the controlled incorporation of both aldehyde substrates into a single major cross-product.

AB - (Figure Presented) A crossing between phases: Polarity makes a difference in distinguishing substrates of otherwise nearly identical chemical reactivities. A one-pot cascade reaction involving nitromethane and two aliphatic aldehydes with similar reactivities has been developed (see scheme). The use of a biphasic reaction medium with two different organic catalysts results in the controlled incorporation of both aldehyde substrates into a single major cross-product.

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Polarity-directed one-pot asymmetric cascade reactions mediated by two catalysts in an aqueous buffer

Abstract

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