Plasmonic nanoholes as SERS devices for biosensing applications: An easy route for nanostructures fabrication on glass substrates

Patrizio Candeloro, Ernesto Iuele, Gerardo Perozziello, Maria Laura Coluccio, Francesco Gentile, Natalia Malara, Vincenzo Mollace, Enzo M. Di Fabrizio

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Surface enhanced Raman spectroscopy (SERS) has been largely exploited in the last decade for biochemical and biomedical research. But some issues still require attention before transferring SERS to bioclinical routinely practices, such as reproducibility, quantitative analysis and signal background interference. In this work we propose an easy and cheap route, based on a template stripping technique, for producing plasmonic nanostructured films with SERS capabilities. We focus our attention to nanoholes in a continuous gold film, conversely to the majority of the literature which is dealing with individual nanostructures. Plasmon resonances occur at the holes edges, thus enabling the possibility of SERS signals from biomolecules and the potential application as biosensors. One advantage of the nanoholes patterned film is the optical-subdiffraction pitch, which prevents any Raman and/or fluorescence signal arising from the bottom slide. This effect paves the way to standard glass slides, much cheaper than CaF2 ones, as suitable substrates for SERS devices, without any interfering signal coming from the glass itself.
Original languageEnglish (US)
Pages (from-to)30-33
Number of pages4
JournalMicroelectronic Engineering
StatePublished - Dec 26 2016

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: Financial support is gratefully acknowledged to National Operative ProgrammePON 04a3_00433 “Exchanger: Share Your Science” and to PON03PE_00078_1, to European project EUROMBR (grant no. 608104), and to Young Researchers project “High Throughput analysis of cancer cells for therapy evaluation by microfluidic platforms integrating plasmonic nanodevices” (CUPJ65C13001350001, project no. GR-2010-2311677) from Italian Ministry of Health.


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