Plasmonic interferometer array biochip as a new mobile medical device for cancer detection

Xie Zeng, Yunchen Yang, Nan Zhang, Dengxin Ji, Xiaodong Gu, Josep Miquel Jornet, Yun Wu, Qiaoqiang Gan

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

We report a plasmonic interferometer array (PIA) sensor and demonstrate its ability to detect circulating exosomal proteins in real-time with high sensitivity and low cost to enable the early detection of cancer. Specifically, a surface plasmon wave launched by the nano-groove rings interferes with the free-space light at the output of central nano-aperture and results in an intensity interference pattern. Under the single-wavelength illumination, when the target exosomal proteins are captured by antibodies bound on the surface, the biomediated change in the refractive index between the central aperture and groove rings causes the intensity change in a transmitted light. By recording the intensity changes in real-time, one can effectively screen biomolecular binding events and analyze the binding kinetics. By integrating signals from multiple sensor pairs to enhance the signal-to-noise ratio, the superior sensing resolutions of 1.63 × 10-6 refractive index unit in a refractive index change and 3.86 × 108 exosomes/mL in exosome detection were realized, respectively. Importantly, this PIA sensor can be imaged by a miniaturized microscope system coupled with a smartphone to realize a portable and highly sensitive healthcare device. The sensing resolution of 9.72 × 109 exosomes/mL in exosome detection was realized using the portable sensing system building upon a commercial smartphone.
Original languageEnglish (US)
JournalIEEE Journal of Selected Topics in Quantum Electronics
Volume25
Issue number1
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

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