Pitx2 determines left-right asymmetry of internal organs in vertebrates

Aimee K. Ryan; Bruce Blumberg; Concepción Rodriguez-Esteban; Sayuri Yonei-Tamura; Koji Tamura; Tohru Tsukui; Jennifer De La Peña; Walid Sabbagh; Jason Greenwald; Senyon Choe; Dominic P. Norris; Elizabeth J. Robertson; Ronald M. Evans; Michael G. Rosenfeld; Juan Carlos Izpisúa Belmonte

doi:10.1038/29004

Pitx2 determines left-right asymmetry of internal organs in vertebrates

Aimee K. Ryan, Bruce Blumberg, Concepción Rodriguez-Esteban, Sayuri Yonei-Tamura, Koji Tamura, Tohru Tsukui, Jennifer De La Peña, Walid Sabbagh, Jason Greenwald, Senyon Choe, Dominic P. Norris, Elizabeth J. Robertson, Ronald M. Evans, Michael G. Rosenfeld, Juan Carlos Izpisúa Belmonte^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

457 Scopus citations

Abstract

The handedness of visceral organs is conserved among vertebrates and is regulated by asymmetric signals relayed by molecules such as Shh, Nodal and activin. The gene Pitx2 is expressed in the left lateral plate mesoderm and, subsequently, in the left heart and gut of mouse, chick and Xenopus embryos. Misexpression of Shh and Nodal induces Pitx2 expression, whereas inhibition of activin signalling blocks it. Misexpression of Pitx2 alters the relative position of organs and the direction of body rotation in chick and Xenopus embryos. Changes in Pitx2 expression are evident in mouse mutants with laterality defects. Thus, Pitx2 seems to serve as a critical downstream transcription target that mediates left-right asymmetry in vertebrates.

Original language	English (US)
Pages (from-to)	545-551
Number of pages	7
Journal	NATURE
Volume	394
Issue number	6693
DOIs	https://doi.org/10.1038/29004
State	Published - Aug 6 1998
Externally published	Yes

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Ryan, A. K., Blumberg, B., Rodriguez-Esteban, C., Yonei-Tamura, S., Tamura, K., Tsukui, T., De La Peña, J., Sabbagh, W., Greenwald, J., Choe, S., Norris, D. P., Robertson, E. J., Evans, R. M., Rosenfeld, M. G., & Belmonte, J. C. I. (1998). Pitx2 determines left-right asymmetry of internal organs in vertebrates. NATURE, 394(6693), 545-551. https://doi.org/10.1038/29004

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title = "Pitx2 determines left-right asymmetry of internal organs in vertebrates",

abstract = "The handedness of visceral organs is conserved among vertebrates and is regulated by asymmetric signals relayed by molecules such as Shh, Nodal and activin. The gene Pitx2 is expressed in the left lateral plate mesoderm and, subsequently, in the left heart and gut of mouse, chick and Xenopus embryos. Misexpression of Shh and Nodal induces Pitx2 expression, whereas inhibition of activin signalling blocks it. Misexpression of Pitx2 alters the relative position of organs and the direction of body rotation in chick and Xenopus embryos. Changes in Pitx2 expression are evident in mouse mutants with laterality defects. Thus, Pitx2 seems to serve as a critical downstream transcription target that mediates left-right asymmetry in vertebrates.",

author = "Ryan, {Aimee K.} and Bruce Blumberg and Concepci{\'o}n Rodriguez-Esteban and Sayuri Yonei-Tamura and Koji Tamura and Tohru Tsukui and {De La Pe{\~n}a}, Jennifer and Walid Sabbagh and Jason Greenwald and Senyon Choe and Norris, {Dominic P.} and Robertson, {Elizabeth J.} and Evans, {Ronald M.} and Rosenfeld, {Michael G.} and Belmonte, {Juan Carlos Izpis{\'u}a}",

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doi = "10.1038/29004",

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AU - Ryan, Aimee K.

AU - Blumberg, Bruce

AU - Rodriguez-Esteban, Concepción

AU - Yonei-Tamura, Sayuri

AU - Tamura, Koji

AU - Tsukui, Tohru

AU - De La Peña, Jennifer

AU - Sabbagh, Walid

AU - Greenwald, Jason

AU - Choe, Senyon

AU - Norris, Dominic P.

AU - Robertson, Elizabeth J.

AU - Evans, Ronald M.

AU - Rosenfeld, Michael G.

AU - Belmonte, Juan Carlos Izpisúa

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AB - The handedness of visceral organs is conserved among vertebrates and is regulated by asymmetric signals relayed by molecules such as Shh, Nodal and activin. The gene Pitx2 is expressed in the left lateral plate mesoderm and, subsequently, in the left heart and gut of mouse, chick and Xenopus embryos. Misexpression of Shh and Nodal induces Pitx2 expression, whereas inhibition of activin signalling blocks it. Misexpression of Pitx2 alters the relative position of organs and the direction of body rotation in chick and Xenopus embryos. Changes in Pitx2 expression are evident in mouse mutants with laterality defects. Thus, Pitx2 seems to serve as a critical downstream transcription target that mediates left-right asymmetry in vertebrates.

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JO - NATURE

JF - NATURE

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ER -

Pitx2 determines left-right asymmetry of internal organs in vertebrates

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