Physical characterization of oleanolic acid nonsolvate and solvates prepared by solvent recrystallization

Henry H.Y. Tong, H. B. Wu, Y. Zheng, J. Xi, Albert H.L. Chow, Chak K. Chan

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Oleanolic acid is a naturally occurring compound used clinically in China for the treatment of hepatitis B. The solid-state chemistry of oleanolic acid recrystallized from a variety of solvents was investigated. Glassy materials were prepared from dichloromethane and chloroform solvents. The oleanolic acid non-solvate prepared from acetone (OA-acetone), and the two oleanolic acid solvates prepared from methanol (OA-methanol) and ethanol (OA-ethanol) were physicochemically characterized. Upon desolvation, both the methanol and ethanol solvates were found to undergo phase transformation to a crystalline phase similar to OA-acetone around 190-195 °C. The PXRD patterns of commercial pharmaceutical grade OA and the OA-methanol were similar, so the commercial form is probably desolvated oleanolic acid methanol solvate. © 2007 Elsevier B.V. All rights reserved.
Original languageEnglish (US)
Pages (from-to)195-202
Number of pages8
JournalInternational Journal of Pharmaceutics
Volume355
Issue number1-2
DOIs
StatePublished - May 1 2008
Externally publishedYes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-07-06

ASJC Scopus subject areas

  • Pharmaceutical Science

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