Abstract
Oleanolic acid is a naturally occurring compound used clinically in China for the treatment of hepatitis B. The solid-state chemistry of oleanolic acid recrystallized from a variety of solvents was investigated. Glassy materials were prepared from dichloromethane and chloroform solvents. The oleanolic acid non-solvate prepared from acetone (OA-acetone), and the two oleanolic acid solvates prepared from methanol (OA-methanol) and ethanol (OA-ethanol) were physicochemically characterized. Upon desolvation, both the methanol and ethanol solvates were found to undergo phase transformation to a crystalline phase similar to OA-acetone around 190-195 °C. The PXRD patterns of commercial pharmaceutical grade OA and the OA-methanol were similar, so the commercial form is probably desolvated oleanolic acid methanol solvate. © 2007 Elsevier B.V. All rights reserved.
Original language | English (US) |
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Pages (from-to) | 195-202 |
Number of pages | 8 |
Journal | International Journal of Pharmaceutics |
Volume | 355 |
Issue number | 1-2 |
DOIs | |
State | Published - May 1 2008 |
Externally published | Yes |
Bibliographical note
Generated from Scopus record by KAUST IRTS on 2023-07-06ASJC Scopus subject areas
- Pharmaceutical Science