Photoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery

Yevhen Fatieiev; Jonas G. Croissant; Shahad K. Alsaiari; Basem Moosa; Dalaver H. Anjum; Niveen M. Khashab

doi:10.1021/acsami.5b07365

Photoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery

Yevhen Fatieiev, Jonas G. Croissant, Shahad K. Alsaiari, Basem Moosa, Dalaver H. Anjum, Niveen M. Khashab

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Bridged silsesquioxane nanocomposites with tunable morphologies incorporating o-nitrophenylene-ammonium bridges are described. The systematic screening of the sol-gel parameters allowed the material to reach the nanoscale –unlike most reported bridged silsesquioxane materials– with controlled dense and hollow structures of 100 to 200 nm. The hybrid composition of silsesquioxanes with 50% of organic content homogenously distributed in the nanomaterials endowed them with photoresponsive properties. Light irradiation was performed to reverse the surface charge of nanoparticles from +46 to -39 mV via the photoreaction of the organic fragments within the particles, as confirmed by spectroscopic monitorings. Furthermore, such NPs were ap-plied for the first time for the on-demand delivery of plasmid DNA in HeLa cancer cells via light actuation.

Original language	English (US)
Pages (from-to)	24993-24997
Number of pages	5
Journal	ACS Applied Materials & Interfaces
Volume	7
Issue number	45
DOIs	https://doi.org/10.1021/acsami.5b07365
State	Published - Sep 29 2015

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KAUST Repository Item: Exported on 2020-10-01

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10.1021/acsami.5b07365

https://repository.kaust.edu.sa/bitstream/10754/578841/1/acsami2E5b07365.pdf

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@article{c2a935068fa946429e56e6fe9e1c6c6a,

title = "Photoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery",

abstract = "Bridged silsesquioxane nanocomposites with tunable morphologies incorporating o-nitrophenylene-ammonium bridges are described. The systematic screening of the sol-gel parameters allowed the material to reach the nanoscale –unlike most reported bridged silsesquioxane materials– with controlled dense and hollow structures of 100 to 200 nm. The hybrid composition of silsesquioxanes with 50% of organic content homogenously distributed in the nanomaterials endowed them with photoresponsive properties. Light irradiation was performed to reverse the surface charge of nanoparticles from +46 to -39 mV via the photoreaction of the organic fragments within the particles, as confirmed by spectroscopic monitorings. Furthermore, such NPs were ap-plied for the first time for the on-demand delivery of plasmid DNA in HeLa cancer cells via light actuation.",

author = "Yevhen Fatieiev and Croissant, {Jonas G.} and Alsaiari, {Shahad K.} and Basem Moosa and Anjum, {Dalaver H.} and Khashab, {Niveen M.}",

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AU - Fatieiev, Yevhen

AU - Croissant, Jonas G.

AU - Alsaiari, Shahad K.

AU - Moosa, Basem

AU - Anjum, Dalaver H.

AU - Khashab, Niveen M.

N1 - KAUST Repository Item: Exported on 2020-10-01

PY - 2015/9/29

Y1 - 2015/9/29

N2 - Bridged silsesquioxane nanocomposites with tunable morphologies incorporating o-nitrophenylene-ammonium bridges are described. The systematic screening of the sol-gel parameters allowed the material to reach the nanoscale –unlike most reported bridged silsesquioxane materials– with controlled dense and hollow structures of 100 to 200 nm. The hybrid composition of silsesquioxanes with 50% of organic content homogenously distributed in the nanomaterials endowed them with photoresponsive properties. Light irradiation was performed to reverse the surface charge of nanoparticles from +46 to -39 mV via the photoreaction of the organic fragments within the particles, as confirmed by spectroscopic monitorings. Furthermore, such NPs were ap-plied for the first time for the on-demand delivery of plasmid DNA in HeLa cancer cells via light actuation.

AB - Bridged silsesquioxane nanocomposites with tunable morphologies incorporating o-nitrophenylene-ammonium bridges are described. The systematic screening of the sol-gel parameters allowed the material to reach the nanoscale –unlike most reported bridged silsesquioxane materials– with controlled dense and hollow structures of 100 to 200 nm. The hybrid composition of silsesquioxanes with 50% of organic content homogenously distributed in the nanomaterials endowed them with photoresponsive properties. Light irradiation was performed to reverse the surface charge of nanoparticles from +46 to -39 mV via the photoreaction of the organic fragments within the particles, as confirmed by spectroscopic monitorings. Furthermore, such NPs were ap-plied for the first time for the on-demand delivery of plasmid DNA in HeLa cancer cells via light actuation.

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UR - http://pubs.acs.org/doi/10.1021/acsami.5b07365

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JO - ACS Applied Materials & Interfaces

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ER -

Photoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery

Abstract

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UN SDGs

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