Photoredox-Catalyzed Ketyl–Olefin Coupling for the Synthesis of Substituted Chromanols

Eleonora Fava, Masaki Nakajima, Anh L. P. Nguyen, Magnus Rueping

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


A visible light photoredox-catalyzed aldehyde olefin cyclization is reported. The method represents a formal hydroacylation of alkenes and alkynes and provides chromanol derivatives in good yields. The protocol takes advantage of the double role played by trialkylamines (NR3) which act as (i) electron donors for reducing the catalyst and (ii) proton donors to activate the substrate via a proton-coupled electron transfer. © 2016 American Chemical Society.
Original languageEnglish (US)
Pages (from-to)6959-6964
Number of pages6
JournalThe Journal of Organic Chemistry
Issue number16
StatePublished - Jul 21 2016

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: European Research Council[617044]


Dive into the research topics of 'Photoredox-Catalyzed Ketyl–Olefin Coupling for the Synthesis of Substituted Chromanols'. Together they form a unique fingerprint.

Cite this