pH-Sensitive Amphiphilic Block-Copolymers for Transport and Controlled Release of Oxygen

Yogesh Raghunath Patil; Sarah Almahdali; Khanh B. Vu; Georgios Zapsas; Nikolaos Hadjichristidis; Valentin Rodionov

doi:10.1039/c7py00679a

pH-Sensitive Amphiphilic Block-Copolymers for Transport and Controlled Release of Oxygen

Yogesh Raghunath Patil, Sarah Almahdali, Khanh B. Vu, Georgios Zapsas, Nikolaos Hadjichristidis, Valentin Rodionov

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7 Scopus citations

Abstract

Saturated fluorocarbons, their derivatives and emulsions are capable of dissolving anomalously high amounts of oxygen and other gases. The mechanistic aspects of this remarkable effect remain to be explored experimentally. Here, the synthesis of a library of amphiphilic fluorous block-copolymers incorporating different fluorinated monomers is described, and the capacity of these copolymers for oxygen transport in water is systematically investigated. The structure of the fluorous monomer employed was found to have a profound effect on both the oxygen-carrying capacity and the gas release kinetics of the polymer emulsions. Furthermore, the release of O2 from the polymer dispersions could be triggered by changing the pH of the solution. This is the first example of a polymer-based system for controlled release of a non-polar, non-covalently entrapped respiratory gas.

Original language	English (US)
Pages (from-to)	4322-4322
Number of pages	1
Journal	Polym. Chem.
Volume	8
Issue number	30
DOIs	https://doi.org/10.1039/c7py00679a
State	Published - May 31 2017

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KAUST Repository Item: Exported on 2018-05-17
Acknowledgements: This research was supported by King Abdullah University of Science and Technology (KAUST).

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title = "pH-Sensitive Amphiphilic Block-Copolymers for Transport and Controlled Release of Oxygen",

abstract = "Saturated fluorocarbons, their derivatives and emulsions are capable of dissolving anomalously high amounts of oxygen and other gases. The mechanistic aspects of this remarkable effect remain to be explored experimentally. Here, the synthesis of a library of amphiphilic fluorous block-copolymers incorporating different fluorinated monomers is described, and the capacity of these copolymers for oxygen transport in water is systematically investigated. The structure of the fluorous monomer employed was found to have a profound effect on both the oxygen-carrying capacity and the gas release kinetics of the polymer emulsions. Furthermore, the release of O2 from the polymer dispersions could be triggered by changing the pH of the solution. This is the first example of a polymer-based system for controlled release of a non-polar, non-covalently entrapped respiratory gas.",

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AU - Patil, Yogesh Raghunath

AU - Almahdali, Sarah

AU - Vu, Khanh B.

AU - Zapsas, Georgios

AU - Hadjichristidis, Nikolaos

AU - Rodionov, Valentin

N1 - KAUST Repository Item: Exported on 2018-05-17 Acknowledgements: This research was supported by King Abdullah University of Science and Technology (KAUST).

PY - 2017/5/31

Y1 - 2017/5/31

N2 - Saturated fluorocarbons, their derivatives and emulsions are capable of dissolving anomalously high amounts of oxygen and other gases. The mechanistic aspects of this remarkable effect remain to be explored experimentally. Here, the synthesis of a library of amphiphilic fluorous block-copolymers incorporating different fluorinated monomers is described, and the capacity of these copolymers for oxygen transport in water is systematically investigated. The structure of the fluorous monomer employed was found to have a profound effect on both the oxygen-carrying capacity and the gas release kinetics of the polymer emulsions. Furthermore, the release of O2 from the polymer dispersions could be triggered by changing the pH of the solution. This is the first example of a polymer-based system for controlled release of a non-polar, non-covalently entrapped respiratory gas.

AB - Saturated fluorocarbons, their derivatives and emulsions are capable of dissolving anomalously high amounts of oxygen and other gases. The mechanistic aspects of this remarkable effect remain to be explored experimentally. Here, the synthesis of a library of amphiphilic fluorous block-copolymers incorporating different fluorinated monomers is described, and the capacity of these copolymers for oxygen transport in water is systematically investigated. The structure of the fluorous monomer employed was found to have a profound effect on both the oxygen-carrying capacity and the gas release kinetics of the polymer emulsions. Furthermore, the release of O2 from the polymer dispersions could be triggered by changing the pH of the solution. This is the first example of a polymer-based system for controlled release of a non-polar, non-covalently entrapped respiratory gas.

UR - http://hdl.handle.net/10754/625110

UR - http://pubs.rsc.org/en/Content/ArticleLanding/2017/PY/C7PY00679A#!divAbstract

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DO - 10.1039/c7py00679a

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SN - 1759-9954

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EP - 4322

JO - Polym. Chem.

JF - Polym. Chem.

IS - 30

ER -

pH-Sensitive Amphiphilic Block-Copolymers for Transport and Controlled Release of Oxygen

Abstract

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