Perspectives on the evolutionary origin of tetrapod limbs

Javier Capdevila*, Juan Carlos Izpisua Belmonte

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


The study of the origin and evolution of the tetrapod limb has benefited enormously from the confluence of molecular and paleontological data. In the last two decades, our knowledge of the basic molecular mechanisms that control limb development has grown exponentially, and developmental biologists now have the possibility of combining molecular data with many available descriptions of the fossil record of vertebrate fins and limbs. This synthesis of developmental and evolutionary biology has the potential to unveil the sequence of molecular changes that culminated in the adoption of the basic tetrapod limb plan. J. Exp. Zool. (Mol. Dev. Evol.) 288:287-303, 2000. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)287-303
Number of pages17
JournalJournal of Experimental Zoology
Issue number4
StatePublished - Dec 15 2000

ASJC Scopus subject areas

  • Animal Science and Zoology

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