Perspectives of fluorescence spectroscopy for online monitoring in microalgae industry

Marta Sá, Narcis Ferrer-Ledo, Fengzheng Gao, Carlo G. Bertinetto, Jeroen Jansen, João G. Crespo, Rene H. Wijffels, Maria Barbosa, Claudia F. Galinha

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Microalgae industrial production is viewed as a solution for alternative production of nutraceuticals, cosmetics, biofertilizers, and biopolymers. Throughout the years, several technological advances have been implemented, increasing the competitiveness of microalgae industry. However, online monitoring and real-time process control of a microalgae production factory still require further development. In this mini-review, non-destructive tools for online monitoring of cellular agriculture applications are described. Still, the focus is on the use of fluorescence spectroscopy to monitor several parameters (cell concentration, pigments, and lipids) in the microalgae industry. The development presented makes it the most promising solution for monitoring up-and downstream processes, different biological parameters simultaneously, and different microalgae species. The improvements needed for industrial application of this technology are also discussed.
Original languageEnglish (US)
JournalMicrobial Biotechnology
StatePublished - Feb 17 2022
Externally publishedYes

Bibliographical note

KAUST Repository Item: Exported on 2022-04-27
Acknowledged KAUST grant number(s): OSR-2016-CPF-2907-05
Acknowledgements: Financial support provided by the European KBBE FP7 project “D-Factory”; MAGNIFICENT project, funded by the Bio-Based Industries Joint Undertaking under the European Union’s Horizon 2020 research and innovation program (grant agreement No. 745754); King Abdullah University of Science and Technology (KAUST) Office of Sponsored Research (OSR) under award no. OSR-2016-CPF-2907-05; FCT, Portugal, for the Ph.D. Fellow grant SFRH/BD/108894/2015; and Associate Laboratory for Green Chemistry- LAQV which is financed by national funds from FCT/MCTES (UIDB/50006/2020 and UIDP/50006/2020). A special thanks to the companies A4F – Algae for future (Portugal) and NECTON, S.A. (Portugal), for sharing their extensive knowledge.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.


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