Performance characteristics of the IMMULITE 2000 insulin-like growth factor binding protein-3 assay

William E. Owen, William L. Roberts

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background: Insulin-like growth factor binding protein-3 (IGFBP-3) is the chief binding protein for insulin-like growth factors 1 and 2 (IGF-1 and IGF-2). Serum concentrations of IGFBP-3 are regulated by growth hormone (GH) and IGF-1 levels. Serum IGFBP-3 measurements are useful for diagnostic evaluations of short stature in children and acromegaly. Methods: A IGFBP-3 assay for the IMMULITE 2000 analyzer was evaluated for limit of detection, linearity, intra- and interassay imprecision, comparison to another commercially available assay, interference studies, and an adult reference interval. Results: The limit of detection was 0.006 mg/l. The assay was linear from 0.01 to 15.1 mg/l. The total interassay imprecision was
Original languageEnglish (US)
Pages (from-to)141-145
Number of pages5
JournalClinica Chimica Acta
Volume353
Issue number1-2
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-09-20

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

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