Performance characteristics of the IMMULITE 2000 insulin-like growth factor binding protein-3 assay

William E. Owen; William L. Roberts

doi:10.1016/j.cccn.2004.10.014

Performance characteristics of the IMMULITE 2000 insulin-like growth factor binding protein-3 assay

William E. Owen, William L. Roberts

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Background: Insulin-like growth factor binding protein-3 (IGFBP-3) is the chief binding protein for insulin-like growth factors 1 and 2 (IGF-1 and IGF-2). Serum concentrations of IGFBP-3 are regulated by growth hormone (GH) and IGF-1 levels. Serum IGFBP-3 measurements are useful for diagnostic evaluations of short stature in children and acromegaly. Methods: A IGFBP-3 assay for the IMMULITE 2000 analyzer was evaluated for limit of detection, linearity, intra- and interassay imprecision, comparison to another commercially available assay, interference studies, and an adult reference interval. Results: The limit of detection was 0.006 mg/l. The assay was linear from 0.01 to 15.1 mg/l. The total interassay imprecision was

Original language	English (US)
Pages (from-to)	141-145
Number of pages	5
Journal	Clinica Chimica Acta
Volume	353
Issue number	1-2
DOIs	https://doi.org/10.1016/j.cccn.2004.10.014
State	Published - Jan 1 2005
Externally published	Yes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-09-20

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Biochemistry, medical

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10.1016/j.cccn.2004.10.014

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title = "Performance characteristics of the IMMULITE 2000 insulin-like growth factor binding protein-3 assay",

abstract = "Background: Insulin-like growth factor binding protein-3 (IGFBP-3) is the chief binding protein for insulin-like growth factors 1 and 2 (IGF-1 and IGF-2). Serum concentrations of IGFBP-3 are regulated by growth hormone (GH) and IGF-1 levels. Serum IGFBP-3 measurements are useful for diagnostic evaluations of short stature in children and acromegaly. Methods: A IGFBP-3 assay for the IMMULITE 2000 analyzer was evaluated for limit of detection, linearity, intra- and interassay imprecision, comparison to another commercially available assay, interference studies, and an adult reference interval. Results: The limit of detection was 0.006 mg/l. The assay was linear from 0.01 to 15.1 mg/l. The total interassay imprecision was",

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doi = "10.1016/j.cccn.2004.10.014",

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T1 - Performance characteristics of the IMMULITE 2000 insulin-like growth factor binding protein-3 assay

AU - Owen, William E.

AU - Roberts, William L.

N1 - Generated from Scopus record by KAUST IRTS on 2023-09-20

PY - 2005/1/1

Y1 - 2005/1/1

N2 - Background: Insulin-like growth factor binding protein-3 (IGFBP-3) is the chief binding protein for insulin-like growth factors 1 and 2 (IGF-1 and IGF-2). Serum concentrations of IGFBP-3 are regulated by growth hormone (GH) and IGF-1 levels. Serum IGFBP-3 measurements are useful for diagnostic evaluations of short stature in children and acromegaly. Methods: A IGFBP-3 assay for the IMMULITE 2000 analyzer was evaluated for limit of detection, linearity, intra- and interassay imprecision, comparison to another commercially available assay, interference studies, and an adult reference interval. Results: The limit of detection was 0.006 mg/l. The assay was linear from 0.01 to 15.1 mg/l. The total interassay imprecision was

AB - Background: Insulin-like growth factor binding protein-3 (IGFBP-3) is the chief binding protein for insulin-like growth factors 1 and 2 (IGF-1 and IGF-2). Serum concentrations of IGFBP-3 are regulated by growth hormone (GH) and IGF-1 levels. Serum IGFBP-3 measurements are useful for diagnostic evaluations of short stature in children and acromegaly. Methods: A IGFBP-3 assay for the IMMULITE 2000 analyzer was evaluated for limit of detection, linearity, intra- and interassay imprecision, comparison to another commercially available assay, interference studies, and an adult reference interval. Results: The limit of detection was 0.006 mg/l. The assay was linear from 0.01 to 15.1 mg/l. The total interassay imprecision was

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DO - 10.1016/j.cccn.2004.10.014

M3 - Article

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JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

IS - 1-2

ER -

Performance characteristics of the IMMULITE 2000 insulin-like growth factor binding protein-3 assay

Abstract

Bibliographical note

ASJC Scopus subject areas

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