Performance characteristics of six third-generation assays for thyroid-stimulating hormone

Mindy L. Rawlins; William L. Roberts

doi:10.1373/clinchem.2004.039156

Performance characteristics of six third-generation assays for thyroid-stimulating hormone

Mindy L. Rawlins, William L. Roberts

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

Background: Thyroid-stimulating hormone (TSH) is used to detect primary hypo- and hyperthyroidism. Current guidelines for TSH assays recommend a functional sensitivity of ≤0.02 mIU/L. The protocol for determining the functional sensitivity of TSH assays specifies analyses of serum samples with two reagent lots over a 6- to 8-week period. Methods: We determined the functional sensitivities of the Access 2, ADVIA Centaur, ARCHITECT i2000, E170, IMMULITE 2000, and Vitros ECi automated methods, using seven serum pools and two reagent lots for each method. Results: The observed functional sensitivities were as follows: Access 2,

Original language	English (US)
Pages (from-to)	2338-2344
Number of pages	7
Journal	Clinical Chemistry
Volume	50
Issue number	12
DOIs	https://doi.org/10.1373/clinchem.2004.039156
State	Published - Dec 1 2004
Externally published	Yes

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Generated from Scopus record by KAUST IRTS on 2023-09-20

ASJC Scopus subject areas

Clinical Biochemistry
Biochemistry, medical

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10.1373/clinchem.2004.039156

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abstract = "Background: Thyroid-stimulating hormone (TSH) is used to detect primary hypo- and hyperthyroidism. Current guidelines for TSH assays recommend a functional sensitivity of ≤0.02 mIU/L. The protocol for determining the functional sensitivity of TSH assays specifies analyses of serum samples with two reagent lots over a 6- to 8-week period. Methods: We determined the functional sensitivities of the Access 2, ADVIA Centaur, ARCHITECT i2000, E170, IMMULITE 2000, and Vitros ECi automated methods, using seven serum pools and two reagent lots for each method. Results: The observed functional sensitivities were as follows: Access 2,",

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AU - Roberts, William L.

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PY - 2004/12/1

Y1 - 2004/12/1

N2 - Background: Thyroid-stimulating hormone (TSH) is used to detect primary hypo- and hyperthyroidism. Current guidelines for TSH assays recommend a functional sensitivity of ≤0.02 mIU/L. The protocol for determining the functional sensitivity of TSH assays specifies analyses of serum samples with two reagent lots over a 6- to 8-week period. Methods: We determined the functional sensitivities of the Access 2, ADVIA Centaur, ARCHITECT i2000, E170, IMMULITE 2000, and Vitros ECi automated methods, using seven serum pools and two reagent lots for each method. Results: The observed functional sensitivities were as follows: Access 2,

AB - Background: Thyroid-stimulating hormone (TSH) is used to detect primary hypo- and hyperthyroidism. Current guidelines for TSH assays recommend a functional sensitivity of ≤0.02 mIU/L. The protocol for determining the functional sensitivity of TSH assays specifies analyses of serum samples with two reagent lots over a 6- to 8-week period. Methods: We determined the functional sensitivities of the Access 2, ADVIA Centaur, ARCHITECT i2000, E170, IMMULITE 2000, and Vitros ECi automated methods, using seven serum pools and two reagent lots for each method. Results: The observed functional sensitivities were as follows: Access 2,

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Performance characteristics of six third-generation assays for thyroid-stimulating hormone

Abstract

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ASJC Scopus subject areas

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