Performance characteristics of six third-generation assays for thyroid-stimulating hormone

Mindy L. Rawlins, William L. Roberts

Research output: Contribution to journalArticlepeer-review

90 Scopus citations


Background: Thyroid-stimulating hormone (TSH) is used to detect primary hypo- and hyperthyroidism. Current guidelines for TSH assays recommend a functional sensitivity of ≤0.02 mIU/L. The protocol for determining the functional sensitivity of TSH assays specifies analyses of serum samples with two reagent lots over a 6- to 8-week period. Methods: We determined the functional sensitivities of the Access 2, ADVIA Centaur, ARCHITECT i2000, E170, IMMULITE 2000, and Vitros ECi automated methods, using seven serum pools and two reagent lots for each method. Results: The observed functional sensitivities were as follows: Access 2,
Original languageEnglish (US)
Pages (from-to)2338-2344
Number of pages7
JournalClinical Chemistry
Issue number12
StatePublished - Dec 1 2004
Externally publishedYes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-09-20

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical


Dive into the research topics of 'Performance characteristics of six third-generation assays for thyroid-stimulating hormone'. Together they form a unique fingerprint.

Cite this