Performance characteristics of an automated high-sensitivity C-reactive protein assay on the Dimension RXL analyzer

Barun K. De; Linda G. Smith; William E. Owen; William L. Roberts

doi:10.1016/S0009-8981(02)00185-7

Performance characteristics of an automated high-sensitivity C-reactive protein assay on the Dimension RXL analyzer

Barun K. De, Linda G. Smith, William E. Owen, William L. Roberts

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Background: C-reactive protein (CRP) is a nonspecific marker of inflammation that can be used as a marker for atherosclerotic risk. This application requires increased precision at low CRP concentrations compared to traditional assays. Methods: The Dimension RXL is an automated chemistry analyzer for central laboratory use. The limit of detection, limit of quantification, linearity and imprecision of a high-sensitivity CRP assay developed for it were assessed. Method comparison studies were performed using samples both inside and outside the reference interval. The presence of a prozone effect was also evaluated. Results: The limit of detection was 0.7 mg/l. The method was linear from 2 to 60 mg/l and from 1 to 60 mg/l using systematic error limits of 10% and 20%, respectively. The total imprecision was

Original language	English (US)
Pages (from-to)	151-155
Number of pages	5
Journal	Clinica Chimica Acta
Volume	323
Issue number	1-2
DOIs	https://doi.org/10.1016/S0009-8981(02)00185-7
State	Published - Aug 3 2002
Externally published	Yes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-09-20

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Biochemistry, medical

Access to Document

10.1016/S0009-8981(02)00185-7

Cite this

@article{d78999662d81409aa06dbd166ab8377d,

title = "Performance characteristics of an automated high-sensitivity C-reactive protein assay on the Dimension RXL analyzer",

abstract = "Background: C-reactive protein (CRP) is a nonspecific marker of inflammation that can be used as a marker for atherosclerotic risk. This application requires increased precision at low CRP concentrations compared to traditional assays. Methods: The Dimension RXL is an automated chemistry analyzer for central laboratory use. The limit of detection, limit of quantification, linearity and imprecision of a high-sensitivity CRP assay developed for it were assessed. Method comparison studies were performed using samples both inside and outside the reference interval. The presence of a prozone effect was also evaluated. Results: The limit of detection was 0.7 mg/l. The method was linear from 2 to 60 mg/l and from 1 to 60 mg/l using systematic error limits of 10% and 20%, respectively. The total imprecision was",

author = "De, {Barun K.} and Smith, {Linda G.} and Owen, {William E.} and Roberts, {William L.}",

note = "Generated from Scopus record by KAUST IRTS on 2023-09-20",

year = "2002",

month = aug,

day = "3",

doi = "10.1016/S0009-8981(02)00185-7",

language = "English (US)",

volume = "323",

pages = "151--155",

journal = "Clinica Chimica Acta",

issn = "0009-8981",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - Performance characteristics of an automated high-sensitivity C-reactive protein assay on the Dimension RXL analyzer

AU - De, Barun K.

AU - Smith, Linda G.

AU - Owen, William E.

AU - Roberts, William L.

N1 - Generated from Scopus record by KAUST IRTS on 2023-09-20

PY - 2002/8/3

Y1 - 2002/8/3

N2 - Background: C-reactive protein (CRP) is a nonspecific marker of inflammation that can be used as a marker for atherosclerotic risk. This application requires increased precision at low CRP concentrations compared to traditional assays. Methods: The Dimension RXL is an automated chemistry analyzer for central laboratory use. The limit of detection, limit of quantification, linearity and imprecision of a high-sensitivity CRP assay developed for it were assessed. Method comparison studies were performed using samples both inside and outside the reference interval. The presence of a prozone effect was also evaluated. Results: The limit of detection was 0.7 mg/l. The method was linear from 2 to 60 mg/l and from 1 to 60 mg/l using systematic error limits of 10% and 20%, respectively. The total imprecision was

AB - Background: C-reactive protein (CRP) is a nonspecific marker of inflammation that can be used as a marker for atherosclerotic risk. This application requires increased precision at low CRP concentrations compared to traditional assays. Methods: The Dimension RXL is an automated chemistry analyzer for central laboratory use. The limit of detection, limit of quantification, linearity and imprecision of a high-sensitivity CRP assay developed for it were assessed. Method comparison studies were performed using samples both inside and outside the reference interval. The presence of a prozone effect was also evaluated. Results: The limit of detection was 0.7 mg/l. The method was linear from 2 to 60 mg/l and from 1 to 60 mg/l using systematic error limits of 10% and 20%, respectively. The total imprecision was

UR - https://linkinghub.elsevier.com/retrieve/pii/S0009898102001857

UR - http://www.scopus.com/inward/record.url?scp=0036067039&partnerID=8YFLogxK

U2 - 10.1016/S0009-8981(02)00185-7

DO - 10.1016/S0009-8981(02)00185-7

M3 - Article

SN - 0009-8981

VL - 323

SP - 151

EP - 155

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

IS - 1-2

ER -

Performance characteristics of an automated high-sensitivity C-reactive protein assay on the Dimension RXL analyzer

Abstract

Bibliographical note

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this