Pentavalent antimony-mannan conjugate therapy of experimental visceral leishmaniasis

William L. Roberts, June Hariprashad, Petrie M. Rainey, Henry W. Murray

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Pentavalent antimony-mannan (Sb[V]-mannan) was 10-fold more potent than sodium stibogluconate in a murine model of visceral leishmaniasis. Liver antimony concentrations were six fold higher after Sb[V]-mannan therapy compared with a dose of sodium stibogluconate that was equipotent in reducing liver parasite burdens. Murine toxicity of Sb[V]-mannan was variable, with a 50% lethal dose (LD50) for one preparation that was well above the concentration that killed 90% of the parasites, and for another preparation was only modestly higher than the concentration that killed 90% of the parasites.
Original languageEnglish (US)
Pages (from-to)444-446
Number of pages3
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume55
Issue number4
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-09-20

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology
  • Parasitology

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