Abstract
Pentavalent antimony-mannan (Sb[V]-mannan) was 10-fold more potent than sodium stibogluconate in a murine model of visceral leishmaniasis. Liver antimony concentrations were six fold higher after Sb[V]-mannan therapy compared with a dose of sodium stibogluconate that was equipotent in reducing liver parasite burdens. Murine toxicity of Sb[V]-mannan was variable, with a 50% lethal dose (LD50) for one preparation that was well above the concentration that killed 90% of the parasites, and for another preparation was only modestly higher than the concentration that killed 90% of the parasites.
Original language | English (US) |
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Pages (from-to) | 444-446 |
Number of pages | 3 |
Journal | American Journal of Tropical Medicine and Hygiene |
Volume | 55 |
Issue number | 4 |
DOIs | |
State | Published - Jan 1 1996 |
Externally published | Yes |
Bibliographical note
Generated from Scopus record by KAUST IRTS on 2023-09-20ASJC Scopus subject areas
- Infectious Diseases
- Virology
- Parasitology