@inproceedings{7d298c096c784c2486f49dc1f9e498c6,
title = "Particulate drug delivery systems for P/M medical combination devices",
abstract = "P/M technology is used in orthopedic implants to create porous surfaces for bone ingrowth. However, these porous surfaces can be exploited for the storage of biofunctional particles in order to generate multifunctional surfaces needed to fight against peri-implant infection or enhance osseointegration. The morphology and release kinetics of several drug delivery systems combining poly(lactide-co-glycolide) particles with porous metallic surfaces were compared to investigate their use for P/M medical combination devices. The drug loaded poly(lactide-co-glycolide) microparticles were produced by an oil-in-water emulsion/solvent evaporation method. The larger particles (26±10 μm) showed a triphasic drug release profile regardless of the type of surface they were attached to, and a sustained release could be achieved for at least 650 hours. The smaller particles (0.6±0.3 μm) attached to a surface having a pore size of 1.1±0.3 μm showed only burst release kinetics of the encapsulated drug. The applications of such systems for porous surfaces obtained by P/M technology are discussed.",
author = "G. Dawes and Fratila-Apachitei, {L. E.} and I. Apachitei and Witkamp, {G. J.} and J. Duszczyk",
year = "2009",
language = "English (US)",
isbn = "9781899072088",
series = "Proceedings of the Euro International Powder Metallurgy Congress and Exhibition, Euro PM 2009",
publisher = "European Powder Metallurgy Association (EPMA)",
booktitle = "Proceedings of the Euro International Powder Metallurgy Congress and Exhibition, Euro PM 2009",
note = "European International Powder Metallurgy Congress and Exhibition, Euro PM 2009 ; Conference date: 12-10-2009 Through 14-10-2009",
}