Since its publication in 1998, the genome sequence of the Mycobacterium tuberculosis H37Rv laboratory strain has acted as the cornerstone for the study of tuberculosis. In this review we address some of the practical aspects that have come to light relating to the use of H37Rv throughout the past decade which are of relevance for the ongoing genomic and laboratory studies of this pathogen. These include errors in the genome reference sequence and its annotation, as well as the recently detected variation amongst isolates of H37Rv from different laboratories. © 2011 Elsevier B.V..
|Original language||English (US)|
|Number of pages||4|
|Journal||Infection, Genetics and Evolution|
|State||Published - Jun 2012|
Bibliographical noteKAUST Repository Item: Exported on 2020-10-01
Acknowledgements: Claudio U. Koser is a Gates Cambridge Scholar and received additional funding from the Cambridge Philosophical Society, the Cambridge European Trust and Clare Hall, Cambridge. We thank D. Collins, J. Parkhill, F. Spies, and S. Okamo for sharing some of their data. We are also grateful to S. Gagneux for proofreading this paper.
ASJC Scopus subject areas
- Infectious Diseases
- Ecology, Evolution, Behavior and Systematics
- Molecular Biology
- Microbiology (medical)