Overestimation of hemoglobin in a patient with an IgA-κ monoclonal gammopathy

William L. Roberts, Jo D. Fontenot, Christopher M. Lehman

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


A patient with multiple myeloma had an automated blood count performed on a Coulter STK-S counter that repeatedly failed internal limits for both mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration. The calculated hematocrit agreed with a spun hematocrit, suggesting that the hemoglobin concentration was being overestimated by the automated counter. Measurement of the plasma hemoglobin concentration of the sample, which showed no visible hemolysis, gave a hemoglobin concentration of 32 g/L on the STK-S analyzer. Correction of the whole blood hemoglobin using the plasma hemoglobin gave a value consistent with the hematocrit. The corrected mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration values were within standard limits. This patient's paraprotein was characterized as IgA-κ and was present at a concentration of 61 g/L. The hemoglobin concentration measured on whole blood by Sysmex NE 8000 and Technicon H*1E autoanalyzers agreed reasonably well with the corrected result from the STK- S.
Original languageEnglish (US)
Pages (from-to)616-618
Number of pages3
JournalArchives of Pathology and Laboratory Medicine
Issue number4
StatePublished - Apr 28 2000
Externally publishedYes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-09-20

ASJC Scopus subject areas

  • Medical Laboratory Technology
  • Pathology and Forensic Medicine


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