Overcoming the PEG-addiction: well-defined alternatives to PEG, from structure–property relationships to better defined therapeutics

Matthias Barz; Robert Luxenhofer; Rudolf Zentel; María J. Vicent

doi:10.1039/c0py00406e

Overcoming the PEG-addiction: well-defined alternatives to PEG, from structure–property relationships to better defined therapeutics

Matthias Barz, Robert Luxenhofer, Rudolf Zentel, María J. Vicent

Research output: Contribution to journal › Article › peer-review

363 Scopus citations

Abstract

Synthetic methods in polymer chemistry have evolved tremendously during the last decade. Nowadays more and more attention is devoted to the application of those tools in the development of the next generation of nanomedicines. Nevertheless, poly(ethylene glycol) (PEG) remains the most frequently used polymer for biomedical applications. In this review, we try to summarize recent efforts and developments in controlled polymerisation techniques that may allow alternatives to PEG based systems and can be used to improve the properties of future polymer therapeutics. © 2011 The Royal Society of Chemistry.

Original language	English (US)
Pages (from-to)	1900
Journal	Polymer Chemistry
Volume	2
Issue number	9
DOIs	https://doi.org/10.1039/c0py00406e
State	Published - 2011
Externally published	Yes

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledged KAUST grant number(s): KUK-F1-029-32
Acknowledgements: R.L. gratefully acknowledges support by the King Abdullah University of Science and Technology, KAUST (award no. KUK-F1-029-32) and ongoing support by Prof. R. Jordan. M.B. would like to thank the graduate school of excellence MAINZ, COMATT, IMPRS, the Spanish Ministry Grant (CTQ2007-606019), European Commission FP7-Health program (proposal n. 241919, LIVIMODE) and particularly the cluster of excellence SAMT of Rhineland-Palatina for support and funding.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.

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abstract = "Synthetic methods in polymer chemistry have evolved tremendously during the last decade. Nowadays more and more attention is devoted to the application of those tools in the development of the next generation of nanomedicines. Nevertheless, poly(ethylene glycol) (PEG) remains the most frequently used polymer for biomedical applications. In this review, we try to summarize recent efforts and developments in controlled polymerisation techniques that may allow alternatives to PEG based systems and can be used to improve the properties of future polymer therapeutics. {\textcopyright} 2011 The Royal Society of Chemistry.",

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AU - Vicent, María J.

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledged KAUST grant number(s): KUK-F1-029-32 Acknowledgements: R.L. gratefully acknowledges support by the King Abdullah University of Science and Technology, KAUST (award no. KUK-F1-029-32) and ongoing support by Prof. R. Jordan. M.B. would like to thank the graduate school of excellence MAINZ, COMATT, IMPRS, the Spanish Ministry Grant (CTQ2007-606019), European Commission FP7-Health program (proposal n. 241919, LIVIMODE) and particularly the cluster of excellence SAMT of Rhineland-Palatina for support and funding. This publication acknowledges KAUST support, but has no KAUST affiliated authors.

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ER -

Overcoming the PEG-addiction: well-defined alternatives to PEG, from structure–property relationships to better defined therapeutics

Abstract

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