Oriented collagen fibers direct tumor cell intravasation

Weijing Han, Shaohua Chen, Wei Yuan, Qihui Fan, Jianxiang Tian, Xiaochen Wang, Longqing Chen, Xixiang Zhang, Weili Wei, Ruchuan Liu, Junle Qu, Yang Jiao, Robert H. Austin, Liyu Liu

Research output: Contribution to journalArticlepeer-review

243 Scopus citations


In this work, we constructed a Collagen I-Matrigel composite extracellular matrix (ECM). The composite ECM was used to determine the influence of the local collagen fiber orientation on the collective intravasation ability of tumor cells. We found that the local fiber alignment enhanced cell-ECM interactions. Specifically, metastatic MDA-MB-231 breast cancer cells followed the local fiber alignment direction during the intravasation into rigid Matrigel (∼10 mg/mL protein concentration).
Original languageEnglish (US)
Pages (from-to)11208-11213
Number of pages6
JournalProceedings of the National Academy of Sciences
Issue number40
StatePublished - Sep 23 2016

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: National Cancer Institute[U54CA143803]


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