Oriented collagen fibers direct tumor cell intravasation

Weijing Han; Shaohua Chen; Wei Yuan; Qihui Fan; Jianxiang Tian; Xiaochen Wang; Longqing Chen; Xixiang Zhang; Weili Wei; Ruchuan Liu; Junle Qu; Yang Jiao; Robert H. Austin; Liyu Liu

doi:10.1073/pnas.1610347113

Oriented collagen fibers direct tumor cell intravasation

Weijing Han, Shaohua Chen, Wei Yuan, Qihui Fan, Jianxiang Tian, Xiaochen Wang, Longqing Chen, Xixiang Zhang, Weili Wei, Ruchuan Liu, Junle Qu, Yang Jiao, Robert H. Austin, Liyu Liu

Research output: Contribution to journal › Article › peer-review

269 Scopus citations

Abstract

In this work, we constructed a Collagen I-Matrigel composite extracellular matrix (ECM). The composite ECM was used to determine the influence of the local collagen fiber orientation on the collective intravasation ability of tumor cells. We found that the local fiber alignment enhanced cell-ECM interactions. Specifically, metastatic MDA-MB-231 breast cancer cells followed the local fiber alignment direction during the intravasation into rigid Matrigel (∼10 mg/mL protein concentration).

Original language	English (US)
Pages (from-to)	11208-11213
Number of pages	6
Journal	Proceedings of the National Academy of Sciences
Volume	113
Issue number	40
DOIs	https://doi.org/10.1073/pnas.1610347113
State	Published - Sep 23 2016

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: National Cancer Institute[U54CA143803]

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title = "Oriented collagen fibers direct tumor cell intravasation",

abstract = "In this work, we constructed a Collagen I-Matrigel composite extracellular matrix (ECM). The composite ECM was used to determine the influence of the local collagen fiber orientation on the collective intravasation ability of tumor cells. We found that the local fiber alignment enhanced cell-ECM interactions. Specifically, metastatic MDA-MB-231 breast cancer cells followed the local fiber alignment direction during the intravasation into rigid Matrigel (∼10 mg/mL protein concentration).",

author = "Weijing Han and Shaohua Chen and Wei Yuan and Qihui Fan and Jianxiang Tian and Xiaochen Wang and Longqing Chen and Xixiang Zhang and Weili Wei and Ruchuan Liu and Junle Qu and Yang Jiao and Austin, {Robert H.} and Liyu Liu",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: National Cancer Institute[U54CA143803]",

year = "2016",

month = sep,

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doi = "10.1073/pnas.1610347113",

language = "English (US)",

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TY - JOUR

T1 - Oriented collagen fibers direct tumor cell intravasation

AU - Han, Weijing

AU - Chen, Shaohua

AU - Yuan, Wei

AU - Fan, Qihui

AU - Tian, Jianxiang

AU - Wang, Xiaochen

AU - Chen, Longqing

AU - Zhang, Xixiang

AU - Wei, Weili

AU - Liu, Ruchuan

AU - Qu, Junle

AU - Jiao, Yang

AU - Austin, Robert H.

AU - Liu, Liyu

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: National Cancer Institute[U54CA143803]

PY - 2016/9/23

Y1 - 2016/9/23

N2 - In this work, we constructed a Collagen I-Matrigel composite extracellular matrix (ECM). The composite ECM was used to determine the influence of the local collagen fiber orientation on the collective intravasation ability of tumor cells. We found that the local fiber alignment enhanced cell-ECM interactions. Specifically, metastatic MDA-MB-231 breast cancer cells followed the local fiber alignment direction during the intravasation into rigid Matrigel (∼10 mg/mL protein concentration).

AB - In this work, we constructed a Collagen I-Matrigel composite extracellular matrix (ECM). The composite ECM was used to determine the influence of the local collagen fiber orientation on the collective intravasation ability of tumor cells. We found that the local fiber alignment enhanced cell-ECM interactions. Specifically, metastatic MDA-MB-231 breast cancer cells followed the local fiber alignment direction during the intravasation into rigid Matrigel (∼10 mg/mL protein concentration).

UR - http://hdl.handle.net/10754/622443

UR - http://www.pnas.org/lookup/doi/10.1073/pnas.1610347113

UR - http://www.scopus.com/inward/record.url?scp=84989874792&partnerID=8YFLogxK

U2 - 10.1073/pnas.1610347113

DO - 10.1073/pnas.1610347113

M3 - Article

C2 - 27663743

SN - 0027-8424

VL - 113

SP - 11208

EP - 11213

JO - Proceedings of the National Academy of Sciences

JF - Proceedings of the National Academy of Sciences

IS - 40

ER -

Oriented collagen fibers direct tumor cell intravasation

Abstract

Bibliographical note

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