Organocatalytic enantioselective reduction of pyridines

Magnus Rueping*, Andrey P. Antonchick

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

253 Scopus citations


Metal-free at last! The first enantioselective organocatalytic reduction of pyridine derivatives leads to hexahydrochinolinones and tetrahydropyridines in good yields and with excellent enantioselctivities (up to 92% ee; see scheme). These compounds are starting materials for the synthesis of various natural products.

Original languageEnglish (US)
Pages (from-to)4562-4565
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number24
StatePublished - 2007
Externally publishedYes


  • Bronsted acids
  • Ion-pair catalysis
  • Piperidines
  • Reduction
  • Transfer hydrogenation

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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