Optimization of protocell of silica nanoparticles using 32 factorial designs

Gunjeet Kaur, Goutam Rath, Hemraj Heer, Amit K. Goyal

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The purpose of the research is to carry out systemic optimization of protocells (liposomes entrapped with silica particles). Optimization was carried out using 32 factorial designs for the selection of the optimized protocell composition with reference to particle size distribution and zetapotential. This design was carried out to study the effect of independent variables such as molar ratio of phosphatidylcholine to cholesterol and concentration of silica nanoparticles. A total of nine formulations of protocells were prepared and analyzed using Design expert® software from Stat-Ease, Inc. (Version trial 2010) for the selection of the optimized combination. Contour plots were constructed with independent variables like size and potential. Protocell with 7:3 ratio of phosphatidyl choline to cholesterol and 0.5 mg/ml of silica nanoparticles demonstrated better colloidal behaviors. The findings obtained from the software corresponding to independent variables demonstrated accurate means for the optimization of the pharmaceutical formulations. © 2011 American Association of Pharmaceutical Scientists.
Original languageEnglish (US)
Pages (from-to)167-173
Number of pages7
JournalAAPS PharmSciTech
Issue number1
StatePublished - Mar 1 2012
Externally publishedYes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-10-12

ASJC Scopus subject areas

  • Pharmaceutical Science


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