Optical force on diseased blood cells: Towards the optical sorting of biological matter

J. S. Totero Gongora; Andrea Fratalocchi

doi:10.1016/j.optlaseng.2015.04.019

Optical force on diseased blood cells: Towards the optical sorting of biological matter

J. S. Totero Gongora, Andrea Fratalocchi

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17 Scopus citations

Abstract

By employing a series of massively parallel ab-initio simulations, we study how optical forces act on biological matter subject to morphological disease. As a representative case study, we here consider the case of Plasmodium falciparum on red blood cells (RBC) illuminated by a monochromatic plane wave. Realistic parameters for the geometry and the refractive index are then taken from published experiments. In our theoretical campaign, we study the dependence of the optical force on the disease stage for different incident wavelengths. We show that optical forces change significantly with the disease, with amplitude variation in the hundreds of pN range. Our results open up new avenues for the design of new optical systems for the treatment of human disease. © 2015 Elsevier Ltd.

Original language	English (US)
Pages (from-to)	40-44
Number of pages	5
Journal	Optics and Lasers in Engineering
Volume	76
DOIs	https://doi.org/10.1016/j.optlaseng.2015.04.019
State	Published - May 21 2015

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Electrical and Electronic Engineering
Mechanical Engineering

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10.1016/j.optlaseng.2015.04.019

Cite this

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title = "Optical force on diseased blood cells: Towards the optical sorting of biological matter",

abstract = "By employing a series of massively parallel ab-initio simulations, we study how optical forces act on biological matter subject to morphological disease. As a representative case study, we here consider the case of Plasmodium falciparum on red blood cells (RBC) illuminated by a monochromatic plane wave. Realistic parameters for the geometry and the refractive index are then taken from published experiments. In our theoretical campaign, we study the dependence of the optical force on the disease stage for different incident wavelengths. We show that optical forces change significantly with the disease, with amplitude variation in the hundreds of pN range. Our results open up new avenues for the design of new optical systems for the treatment of human disease. {\textcopyright} 2015 Elsevier Ltd.",

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AU - Gongora, J. S. Totero

AU - Fratalocchi, Andrea

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PY - 2015/5/21

Y1 - 2015/5/21

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AB - By employing a series of massively parallel ab-initio simulations, we study how optical forces act on biological matter subject to morphological disease. As a representative case study, we here consider the case of Plasmodium falciparum on red blood cells (RBC) illuminated by a monochromatic plane wave. Realistic parameters for the geometry and the refractive index are then taken from published experiments. In our theoretical campaign, we study the dependence of the optical force on the disease stage for different incident wavelengths. We show that optical forces change significantly with the disease, with amplitude variation in the hundreds of pN range. Our results open up new avenues for the design of new optical systems for the treatment of human disease. © 2015 Elsevier Ltd.

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DO - 10.1016/j.optlaseng.2015.04.019

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VL - 76

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JO - Optics and Lasers in Engineering

JF - Optics and Lasers in Engineering

ER -

Optical force on diseased blood cells: Towards the optical sorting of biological matter

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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