One-pot synthesis of three-dimensional Mn3O4 microcubes for high-level sensitive detection of head and neck cancer drug nimorazole

Rajaji Umamaheswari, Muthumariappan Akilarasan, Shen Ming Chen, Yi Hui Cheng, Veerappan Mani, Sakthivel Kogularasu, Fahad M.A. Al-Hemaid, M. Ajmal Ali, Xiaoheng Liu

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

We described a three-dimensional Mn3O4 microcubes (3D–Mn3O4MCs) synthesised via a facile hydrothermal route for the determination of nimorazole (NMZ), an important drug that used in the treatment of head and neck cancer. The 3D–Mn3O4 MCs possess large active area and high conductivity, and 3D–Mn3O4 MCs film modified screen-printed carbon electrode (3D–Mn3O4MCs/SPCE) was fabricated which displayed excellent electrocatalytic ability towards NMZ. Under optimised working conditions, the modified electrode responded linearly to NMZ in the 0.025–8060 µM concentration range and the detection limit was 6 nM. A rapid, sensitive, selective, reproducible, and durable sensor was described. The practical feasibility of the sensor was demonstrated in human serum and NMZ tablet samples. The obtained results revealed the potential real-time applicability of the sensing device in biological analysis and pharmaceutical formulations.
Original languageEnglish (US)
Pages (from-to)1193-1201
Number of pages9
JournalJournal of Colloid and Interface Science
Volume505
DOIs
StatePublished - Nov 1 2017
Externally publishedYes

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Generated from Scopus record by KAUST IRTS on 2023-09-21

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