TY - JOUR
T1 - One-pot synthesis of three-dimensional Mn3O4 microcubes for high-level sensitive detection of head and neck cancer drug nimorazole
AU - Umamaheswari, Rajaji
AU - Akilarasan, Muthumariappan
AU - Chen, Shen Ming
AU - Cheng, Yi Hui
AU - Mani, Veerappan
AU - Kogularasu, Sakthivel
AU - Al-Hemaid, Fahad M.A.
AU - Ajmal Ali, M.
AU - Liu, Xiaoheng
N1 - Generated from Scopus record by KAUST IRTS on 2023-09-21
PY - 2017/11/1
Y1 - 2017/11/1
N2 - We described a three-dimensional Mn3O4 microcubes (3D–Mn3O4MCs) synthesised via a facile hydrothermal route for the determination of nimorazole (NMZ), an important drug that used in the treatment of head and neck cancer. The 3D–Mn3O4 MCs possess large active area and high conductivity, and 3D–Mn3O4 MCs film modified screen-printed carbon electrode (3D–Mn3O4MCs/SPCE) was fabricated which displayed excellent electrocatalytic ability towards NMZ. Under optimised working conditions, the modified electrode responded linearly to NMZ in the 0.025–8060 µM concentration range and the detection limit was 6 nM. A rapid, sensitive, selective, reproducible, and durable sensor was described. The practical feasibility of the sensor was demonstrated in human serum and NMZ tablet samples. The obtained results revealed the potential real-time applicability of the sensing device in biological analysis and pharmaceutical formulations.
AB - We described a three-dimensional Mn3O4 microcubes (3D–Mn3O4MCs) synthesised via a facile hydrothermal route for the determination of nimorazole (NMZ), an important drug that used in the treatment of head and neck cancer. The 3D–Mn3O4 MCs possess large active area and high conductivity, and 3D–Mn3O4 MCs film modified screen-printed carbon electrode (3D–Mn3O4MCs/SPCE) was fabricated which displayed excellent electrocatalytic ability towards NMZ. Under optimised working conditions, the modified electrode responded linearly to NMZ in the 0.025–8060 µM concentration range and the detection limit was 6 nM. A rapid, sensitive, selective, reproducible, and durable sensor was described. The practical feasibility of the sensor was demonstrated in human serum and NMZ tablet samples. The obtained results revealed the potential real-time applicability of the sensing device in biological analysis and pharmaceutical formulations.
UR - https://linkinghub.elsevier.com/retrieve/pii/S0021979717307786
UR - http://www.scopus.com/inward/record.url?scp=85024883092&partnerID=8YFLogxK
U2 - 10.1016/j.jcis.2017.07.006
DO - 10.1016/j.jcis.2017.07.006
M3 - Article
SN - 1095-7103
VL - 505
SP - 1193
EP - 1201
JO - Journal of Colloid and Interface Science
JF - Journal of Colloid and Interface Science
ER -
