One-pot dichlorinative deamidation of primary β-ketoamides

Congke Zheng, Xiaohui Zhang, Muhammad Ijaz Hussain, Mingming Huang, Qing Liu, Yan Xiong, Xiangming Zhu

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


An approach to the dichlorinative deamidation of primary β-ketoamides through ketonic cleavage is described, and a series of α,α-dichloroketones were furnished mostly in the presence of TEMPO. Based on control experiments, a mechanism involving tandem dichlorination and deamidation is proposed to interpret the observed reactivity.
Original languageEnglish (US)
Pages (from-to)574-577
Number of pages4
JournalTetrahedron Letters
Issue number6
StatePublished - Jan 1 2017
Externally publishedYes

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Generated from Scopus record by KAUST IRTS on 2023-10-22


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