One-pot dichlorinative deamidation of primary β-ketoamides

Congke Zheng; Xiaohui Zhang; Muhammad Ijaz Hussain; Mingming Huang; Qing Liu; Yan Xiong; Xiangming Zhu

doi:10.1016/j.tetlet.2016.12.087

One-pot dichlorinative deamidation of primary β-ketoamides

Congke Zheng, Xiaohui Zhang, Muhammad Ijaz Hussain, Mingming Huang, Qing Liu, Yan Xiong, Xiangming Zhu

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

An approach to the dichlorinative deamidation of primary β-ketoamides through ketonic cleavage is described, and a series of α,α-dichloroketones were furnished mostly in the presence of TEMPO. Based on control experiments, a mechanism involving tandem dichlorination and deamidation is proposed to interpret the observed reactivity.

Original language	English (US)
Pages (from-to)	574-577
Number of pages	4
Journal	Tetrahedron Letters
Volume	58
Issue number	6
DOIs	https://doi.org/10.1016/j.tetlet.2016.12.087
State	Published - Jan 1 2017
Externally published	Yes

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Generated from Scopus record by KAUST IRTS on 2023-10-22

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10.1016/j.tetlet.2016.12.087

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abstract = "An approach to the dichlorinative deamidation of primary β-ketoamides through ketonic cleavage is described, and a series of α,α-dichloroketones were furnished mostly in the presence of TEMPO. Based on control experiments, a mechanism involving tandem dichlorination and deamidation is proposed to interpret the observed reactivity.",

author = "Congke Zheng and Xiaohui Zhang and {Ijaz Hussain}, Muhammad and Mingming Huang and Qing Liu and Yan Xiong and Xiangming Zhu",

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T1 - One-pot dichlorinative deamidation of primary β-ketoamides

AU - Zheng, Congke

AU - Zhang, Xiaohui

AU - Ijaz Hussain, Muhammad

AU - Huang, Mingming

AU - Liu, Qing

AU - Xiong, Yan

AU - Zhu, Xiangming

N1 - Generated from Scopus record by KAUST IRTS on 2023-10-22

PY - 2017/1/1

Y1 - 2017/1/1

N2 - An approach to the dichlorinative deamidation of primary β-ketoamides through ketonic cleavage is described, and a series of α,α-dichloroketones were furnished mostly in the presence of TEMPO. Based on control experiments, a mechanism involving tandem dichlorination and deamidation is proposed to interpret the observed reactivity.

AB - An approach to the dichlorinative deamidation of primary β-ketoamides through ketonic cleavage is described, and a series of α,α-dichloroketones were furnished mostly in the presence of TEMPO. Based on control experiments, a mechanism involving tandem dichlorination and deamidation is proposed to interpret the observed reactivity.

UR - https://linkinghub.elsevier.com/retrieve/pii/S0040403916317543

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DO - 10.1016/j.tetlet.2016.12.087

M3 - Article

SN - 1873-3581

VL - 58

SP - 574

EP - 577

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 6

ER -

One-pot dichlorinative deamidation of primary β-ketoamides

Abstract

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