Abstract
A one-pot chemoenzymatic sequential cascade for the synthesis of chiral amines from alkynes was developed. In this integrated approach, just ppm amounts of gold catalysts enabled the conversion of alkynes to ketones (>99%) after which a transaminase was used to catalyze the production of biologically valuable chiral amines in a good yield (up to 99%) and enantiomeric excess (>99%). A preparative scale synthesis of (S)-methylbenzylamine and (S)-4-methoxy-methylbenzylamine from its alkyne form gave a yield of 59 and 92%, respectively, with ee > 99%.
Original language | English (US) |
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Pages (from-to) | 12565-12569 |
Number of pages | 5 |
Journal | ACS Catalysis |
DOIs | |
State | Published - Sep 29 2021 |
Bibliographical note
KAUST Repository Item: Exported on 2021-10-05Acknowledged KAUST grant number(s): FCC/1/1974
Acknowledgements: This work was financially supported by the King Abdullah University of Science and Technology (KAUST), Saudi Arabia, Office of Sponsored Research This work was financially supported by the King Abdullah University of Science and Technology (KAUST), Saudi Arabia, Office of Sponsored Research (FCC/1/1974).
ASJC Scopus subject areas
- Catalysis