Omega hydroxylated JA-Ile is an endogenous bioactive jasmonate that signals through the canonical jasmonate signaling pathway

Guillermo H. Jimenez-Aleman, Marilia Almeida-Trapp, Gemma Fernandez-Barbero, Selena Gimenez-Ibanez, Michael Reichelt, Jyothilakshmi Vadassery, Axel Mithoefer, Julio Caballero, Wilhelm Boland, Roberto Solano

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23 Scopus citations

Abstract

Jasmonates are fatty acid derivatives that control several plant processes including growth, development and defense. Despite the chemical diversity of jasmonates, only jasmonoyl-L-isoleucine (JA-Ile) has been clearly characterized as the endogenous ligand of the jasmonate co-receptors (COI1-JAZs) in higher plants. Currently, it is accepted that ω-hydroxylation of JA-Ile leads to inactivation of the molecule. This study shows that ω-hydroxylated JA-Ile (12-OH-JA-Ile) retains bioactivity and signals through the canonical JA-pathway. The results suggest that 12-OH-JA-Ile differentially activates a subset of JA-Ile co-receptors that may control and/or modulate particular jasmonate dependent responses. It is proposed that after a strong immune response mediated by JA-Ile, the ω-hydroxylated form modulates JA-Ile activated processes thereby improving plant resilience.
Original languageEnglish (US)
Pages (from-to)158520
JournalBIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Volume1864
Issue number12
DOIs
StatePublished - 2019

Bibliographical note

KAUST Repository Item: Exported on 2021-07-13
Acknowledgements: Fellowships granted by the DFG to G.H.J.A. (Grant JI 241/2-1) and by CAPES-Humboldt to M.A.T. (Grant 99999.007611/2015-03) are gratefully acknowledged. Work in R. Solano's lab was funded by the Spanish Ministry for Science and Innovation grant BIO2016-77216-R (MINECO/FEDER). The authors thank the Max Planck Society for funding. We thank Andrea Lehr for technical assistance and the MPI-CE greenhouse team for cultivation of plants. The authors thank Prof. T. Heitz for providing the b1b3c1 mutant.

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