Omega hydroxylated JA-Ile is an endogenous bioactive jasmonate that signals through the canonical jasmonate signaling pathway

Guillermo H. Jimenez-Aleman; Marilia Almeida-Trapp; Gemma Fernandez-Barbero; Selena Gimenez-Ibanez; Michael Reichelt; Jyothilakshmi Vadassery; Axel Mithoefer; Julio Caballero; Wilhelm Boland; Roberto Solano

doi:10.1016/j.bbalip.2019.158520

Omega hydroxylated JA-Ile is an endogenous bioactive jasmonate that signals through the canonical jasmonate signaling pathway

Guillermo H. Jimenez-Aleman, Marilia Almeida-Trapp, Gemma Fernandez-Barbero, Selena Gimenez-Ibanez, Michael Reichelt, Jyothilakshmi Vadassery, Axel Mithoefer, Julio Caballero, Wilhelm Boland, Roberto Solano

Biological, Environmental Sciences and Engineering

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Jasmonates are fatty acid derivatives that control several plant processes including growth, development and defense. Despite the chemical diversity of jasmonates, only jasmonoyl-L-isoleucine (JA-Ile) has been clearly characterized as the endogenous ligand of the jasmonate co-receptors (COI1-JAZs) in higher plants. Currently, it is accepted that ω-hydroxylation of JA-Ile leads to inactivation of the molecule. This study shows that ω-hydroxylated JA-Ile (12-OH-JA-Ile) retains bioactivity and signals through the canonical JA-pathway. The results suggest that 12-OH-JA-Ile differentially activates a subset of JA-Ile co-receptors that may control and/or modulate particular jasmonate dependent responses. It is proposed that after a strong immune response mediated by JA-Ile, the ω-hydroxylated form modulates JA-Ile activated processes thereby improving plant resilience.

Original language	English (US)
Pages (from-to)	158520
Journal	BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Volume	1864
Issue number	12
DOIs	https://doi.org/10.1016/j.bbalip.2019.158520
State	Published - 2019

Bibliographical note

KAUST Repository Item: Exported on 2021-07-13
Acknowledgements: Fellowships granted by the DFG to G.H.J.A. (Grant JI 241/2-1) and by CAPES-Humboldt to M.A.T. (Grant 99999.007611/2015-03) are gratefully acknowledged. Work in R. Solano's lab was funded by the Spanish Ministry for Science and Innovation grant BIO2016-77216-R (MINECO/FEDER). The authors thank the Max Planck Society for funding. We thank Andrea Lehr for technical assistance and the MPI-CE greenhouse team for cultivation of plants. The authors thank Prof. T. Heitz for providing the b1b3c1 mutant.

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10.1016/j.bbalip.2019.158520

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Jimenez-Aleman, G. H., Almeida-Trapp, M., Fernandez-Barbero, G., Gimenez-Ibanez, S., Reichelt, M., Vadassery, J., Mithoefer, A., Caballero, J., Boland, W., & Solano, R. (2019). Omega hydroxylated JA-Ile is an endogenous bioactive jasmonate that signals through the canonical jasmonate signaling pathway. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1864(12), 158520. https://doi.org/10.1016/j.bbalip.2019.158520

@article{88e314a9453f438386b07a17c4c03358,

title = "Omega hydroxylated JA-Ile is an endogenous bioactive jasmonate that signals through the canonical jasmonate signaling pathway",

abstract = "Jasmonates are fatty acid derivatives that control several plant processes including growth, development and defense. Despite the chemical diversity of jasmonates, only jasmonoyl-L-isoleucine (JA-Ile) has been clearly characterized as the endogenous ligand of the jasmonate co-receptors (COI1-JAZs) in higher plants. Currently, it is accepted that ω-hydroxylation of JA-Ile leads to inactivation of the molecule. This study shows that ω-hydroxylated JA-Ile (12-OH-JA-Ile) retains bioactivity and signals through the canonical JA-pathway. The results suggest that 12-OH-JA-Ile differentially activates a subset of JA-Ile co-receptors that may control and/or modulate particular jasmonate dependent responses. It is proposed that after a strong immune response mediated by JA-Ile, the ω-hydroxylated form modulates JA-Ile activated processes thereby improving plant resilience.",

author = "Jimenez-Aleman, {Guillermo H.} and Marilia Almeida-Trapp and Gemma Fernandez-Barbero and Selena Gimenez-Ibanez and Michael Reichelt and Jyothilakshmi Vadassery and Axel Mithoefer and Julio Caballero and Wilhelm Boland and Roberto Solano",

note = "KAUST Repository Item: Exported on 2021-07-13 Acknowledgements: Fellowships granted by the DFG to G.H.J.A. (Grant JI 241/2-1) and by CAPES-Humboldt to M.A.T. (Grant 99999.007611/2015-03) are gratefully acknowledged. Work in R. Solano's lab was funded by the Spanish Ministry for Science and Innovation grant BIO2016-77216-R (MINECO/FEDER). The authors thank the Max Planck Society for funding. We thank Andrea Lehr for technical assistance and the MPI-CE greenhouse team for cultivation of plants. The authors thank Prof. T. Heitz for providing the b1b3c1 mutant.",

year = "2019",

doi = "10.1016/j.bbalip.2019.158520",

language = "English (US)",

volume = "1864",

pages = "158520",

journal = "BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS",

issn = "1879-2618",

number = "12",

}

Jimenez-Aleman, GH, Almeida-Trapp, M, Fernandez-Barbero, G, Gimenez-Ibanez, S, Reichelt, M, Vadassery, J, Mithoefer, A, Caballero, J, Boland, W & Solano, R 2019, 'Omega hydroxylated JA-Ile is an endogenous bioactive jasmonate that signals through the canonical jasmonate signaling pathway', BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, vol. 1864, no. 12, pp. 158520. https://doi.org/10.1016/j.bbalip.2019.158520

Omega hydroxylated JA-Ile is an endogenous bioactive jasmonate that signals through the canonical jasmonate signaling pathway. / Jimenez-Aleman, Guillermo H.; Almeida-Trapp, Marilia; Fernandez-Barbero, Gemma et al.
In: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, Vol. 1864, No. 12, 2019, p. 158520.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Omega hydroxylated JA-Ile is an endogenous bioactive jasmonate that signals through the canonical jasmonate signaling pathway

AU - Jimenez-Aleman, Guillermo H.

AU - Almeida-Trapp, Marilia

AU - Fernandez-Barbero, Gemma

AU - Gimenez-Ibanez, Selena

AU - Reichelt, Michael

AU - Vadassery, Jyothilakshmi

AU - Mithoefer, Axel

AU - Caballero, Julio

AU - Boland, Wilhelm

AU - Solano, Roberto

N1 - KAUST Repository Item: Exported on 2021-07-13 Acknowledgements: Fellowships granted by the DFG to G.H.J.A. (Grant JI 241/2-1) and by CAPES-Humboldt to M.A.T. (Grant 99999.007611/2015-03) are gratefully acknowledged. Work in R. Solano's lab was funded by the Spanish Ministry for Science and Innovation grant BIO2016-77216-R (MINECO/FEDER). The authors thank the Max Planck Society for funding. We thank Andrea Lehr for technical assistance and the MPI-CE greenhouse team for cultivation of plants. The authors thank Prof. T. Heitz for providing the b1b3c1 mutant.

PY - 2019

Y1 - 2019

N2 - Jasmonates are fatty acid derivatives that control several plant processes including growth, development and defense. Despite the chemical diversity of jasmonates, only jasmonoyl-L-isoleucine (JA-Ile) has been clearly characterized as the endogenous ligand of the jasmonate co-receptors (COI1-JAZs) in higher plants. Currently, it is accepted that ω-hydroxylation of JA-Ile leads to inactivation of the molecule. This study shows that ω-hydroxylated JA-Ile (12-OH-JA-Ile) retains bioactivity and signals through the canonical JA-pathway. The results suggest that 12-OH-JA-Ile differentially activates a subset of JA-Ile co-receptors that may control and/or modulate particular jasmonate dependent responses. It is proposed that after a strong immune response mediated by JA-Ile, the ω-hydroxylated form modulates JA-Ile activated processes thereby improving plant resilience.

AB - Jasmonates are fatty acid derivatives that control several plant processes including growth, development and defense. Despite the chemical diversity of jasmonates, only jasmonoyl-L-isoleucine (JA-Ile) has been clearly characterized as the endogenous ligand of the jasmonate co-receptors (COI1-JAZs) in higher plants. Currently, it is accepted that ω-hydroxylation of JA-Ile leads to inactivation of the molecule. This study shows that ω-hydroxylated JA-Ile (12-OH-JA-Ile) retains bioactivity and signals through the canonical JA-pathway. The results suggest that 12-OH-JA-Ile differentially activates a subset of JA-Ile co-receptors that may control and/or modulate particular jasmonate dependent responses. It is proposed that after a strong immune response mediated by JA-Ile, the ω-hydroxylated form modulates JA-Ile activated processes thereby improving plant resilience.

UR - http://hdl.handle.net/10754/670128

UR - https://linkinghub.elsevier.com/retrieve/pii/S138819811930160X

UR - http://www.scopus.com/inward/record.url?scp=85071839680&partnerID=8YFLogxK

U2 - 10.1016/j.bbalip.2019.158520

DO - 10.1016/j.bbalip.2019.158520

M3 - Article

SN - 1879-2618

VL - 1864

SP - 158520

JO - BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

JF - BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

IS - 12

ER -

Omega hydroxylated JA-Ile is an endogenous bioactive jasmonate that signals through the canonical jasmonate signaling pathway

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