Abstract
Novel PEGylated pH-sensitive poly[methacrylic acid-co-poly(ethylene glycol) methyl ether methacrylate] [P(MAA-co-PEGMA)] hollow microspheres were synthesized by a two-stage distillation precipitation polymerization. PMAA@P(MAA-co-PEGMA) core shell microspheres were synthesized by the second-stage polymerization of MAA and PEGMA, using the N,N′- methylenebisacrylamide (MBAAm) as crosslinker in the presence of non-crosslinked PMAA microspheres. The cavity was formed by selective removal of PMAA core in ethanol. The resulted PEGylated hollow microspheres were characterized with Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FT-IR). The shrink and swelling behavior under different pH was studied by Dynamic Light Scattering (DLS).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 180-183 |
| Number of pages | 4 |
| Journal | Materials Letters |
| Volume | 67 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 15 2012 |
| Externally published | Yes |
Bibliographical note
Funding Information:We thank the European Research Council (ERC) for financial support of this work under the “IDEAS” project called “A Novel Nano-container drug carrier for targeted treatment of prostate cancer” with the acronym NANOTHERAPY and the reference number 232959 .
Keywords
- Hollow microspheres
- PEG
- PEGylated
- PMAA
- Polymer
- pH-sensitive
ASJC Scopus subject areas
- General Materials Science
- Condensed Matter Physics
- Mechanics of Materials
- Mechanical Engineering